ArticleFrontiers in cellular neuroscience2014
Firing clamp: a novel method for single-trial estimation of excitatory and inhibitory synaptic neuronal conductances.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
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4 citing papers in PubMed.
- Complex excitability and "flipping" of granule cells: An experimental and computational study.PloS one · 2026Article
- Observing hidden neuronal states in experiments.PLoS computational biology · 2025Article
- Determination of effective synaptic conductances using somatic voltage clamp.PLoS computational biology · 2019Article
- Synaptic Conductances during Interictal Discharges in Pyramidal Neurons of Rat Entorhinal Cortex.Frontiers in cellular neuroscience · 2016Article
Corrections and comments
- Erratum issued
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5 authors.
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Abstract
Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording. For this purpose, we propose a new intracellular recording method, called "firing clamp." Synaptic conductances are estimated from the characteristics of artificially evoked probe spikes, namely the spike amplitude and the mean subthreshold potential, which are sensitive to both excitatory and inhibitory synaptic input signals. The probe spikes, timed at a fixed rate, are evoked in the dynamic-clamp mode by injected meander-like current steps, with the step duration depending on neuronal membrane voltage. We test the method with perforated-patch recordings from isolated cells stimulated by external application or synaptic release of transmitter, and validate the method with simulations of a biophysically-detailed neuron model. The results are compared with the conductance estimates based on conventional current-clamp recordings.
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