SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2014
Prader Willi syndrome and obstructive sleep apnea: co-occurrence in the pediatric population.
Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04118816 (Impact of Sleep-disordered Breathing on Autonomic Regulation in Patients With Prader-Willi Syndrome), which is not on this map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Sleep-disordered Breathing on Autonomic Regulation in Patients With Prader-Willi Syndrome
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.
- Sleep disorders in rare genetic syndromes: a meta-analysis of prevalence and profile.Molecular autism · 2021Pooled it
- Early oxytocin treatment in infants with Prader-Willi syndrome is safe and is associated with better endocrine, metabolic and behavioral outcomes.Orphanet journal of rare diseases · 2025Trial
- Prevalence of sleep-disordered breathing in children and adolescents with large horizontal maxillary overjet due to mandibular retrognathia: a case-control study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Trial
- Obstructive sleep apnoea severity and insulin resistance in children with Prader-Willi Syndrome: the SPISE index as a candidate metabolic marker.European journal of pediatrics · 2026Article
- The Power of Pediatric Sleep: Shaping Healthy Evidence-Based 24/7 Lifestyles for Generation Alpha.Pediatric discovery · 2025Article
- Cardiovascular autonomic dysfunction and sleep abnormalities in children with Prader-Willi syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Assessment of Positional Obstructive Sleep Apnea in Children Undergoing Adenotonsillectomy for Obstructive Sleep Apnea.Laryngoscope investigative otolaryngology · 2025Article
- Risk and Protective Factors for Obstructive Sleep Apnea Syndrome Throughout Lifespan: From Pregnancy to Adolescence.Children (Basel, Switzerland) · 2025Review
- Sleep and circadian disturbances in children with neurodevelopmental disorders.Nature reviews. Neurology · 2025Review
- Give me five! A modern perspective on addiction from the up-dated Freudian drive theory.Frontiers in psychiatry · 2025Article
- Assessment of Changes in Behavior and Quality of Life after Monobloc Treatment in Children with Obstructive Sleep Apnea or Primary Snoring.Turkish journal of orthodontics · 2024Article
- Paediatric sleep diagnostics in the 21st century: the era of "sleep-omics"?European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Orthodontic and Facial Characteristics of Craniofacial Syndromic Children with Obstructive Sleep Apnea.Diagnostics (Basel, Switzerland) · 2023Article
- Pediatric Sleep Respiratory Disorders: A Narrative Review of Epidemiology and Risk Factors.Children (Basel, Switzerland) · 2023Review
- Sleep Consequences of Prader-Willi Syndrome.Current neurology and neuroscience reports · 2023Review
- Candidate genes for obstructive sleep apnea in non-syndromic children with craniofacial dysmorphisms - a narrative review.Frontiers in pediatrics · 2023Review
- Prevalence of Sleep-Disordered Breathing in Prader-Willi Syndrome.Canadian respiratory journal · 2023Article
- Demographics and medical comorbidities among hospitalized patients with Prader-Willi Syndrome: A National Inpatient Sample analysis.American journal of medical genetics. Part A · 2022Article
- Body composition and obstructive sleep apnoea assessment in adult patients with Prader-Willi syndrome: a case control study.Journal of endocrinological investigation · 2022Article
- Preserved Sleep for the Same Level of Respiratory Disturbance in Children with Prader-Willi Syndrome.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA high prevalence of obstructive sleep apnea (OSA) occurs in children with Prader-Willi syndrome (PWS). Yet, due in part to the relatively small samples previously used, the prevalence of OSA has varied greatly across studies. It is also unclear if factors such as age, gender, body mass index (BMI), or type of genetic imprinting are associated with increased risk for OSA among children with PWS.
objectivesTo evaluate the (a) prevalence of OSA, as well as narcolepsy, in pediatric populations diagnosed with PWS; (b) effects of age, gender, body mass index, and genetic imprinting on OSA severity; and (c) efficacy of adenotonsillectomy (AT) for decreasing OSA severity in this population.
methodsAll studies assessing OSA among children with PWS through August 2013 were identified using the PubMed/Medline, Psych Info, Cochrane library, and Google Scholar data bases.
resultsFourteen studies of children diagnosed with PWS and who were assessed for OSA using polysomnography (PSG) met inclusion criteria (n = 224 children). The prevalence of OSA across studies was 79.91% (n = 179/224). Among youths with OSA, 53.07% had mild OSA, 22.35% moderate OSA, and 24.58% severe OSA. Narcolepsy was found to occur in 35.71% of children with PWS. Adenotonsillectomy was associated with improvement in OSA for most children with PWS. However, residual OSA was present in the majority of cases post-surgery.
conclusionThis study confirms the high prevalence of OSA and narcolepsy among children with PWS. Screening for OSA and narcolepsy among children with PWS is recommended. In addition, while adenotonsillectomy was effective in reducing OSA for some children, alternative treatments may need to be considered, given the only moderate response rate.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.