Evidence map›Paper›PMID 24733985›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2014

Comparison of BMI, AHI, and apolipoprotein E ε4 (APOE-ε4) alleles among sleep apnea patients with different skeletal classifications.

Jason J Roedig, Barbara A Phillips, Lorri A Morford, Joseph E Van Sickels, Gabriel Falcao-Alencar, David W Fardo, James K Hartsfield, Xiuhua Ding, G Thomas Kluemper

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Evaluation of clinical and genetic factors in obstructive sleep apnoea.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023
    Article
  3. Review
  4. Distribution ofThe Indian journal of medical research · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jason J RoedigCollege of Dentistry, University of Kentucky, Lexington, KY.
Barbara A PhillipsCollege of Medicine, University of Kentucky, Lexington, KY.
Lorri A MorfordCollege of Dentistry, University of Kentucky, Lexington, KY.
Joseph E Van SickelsCollege of Dentistry, University of Kentucky, Lexington, KY.
Gabriel Falcao-AlencarCollege of Dentistry, University of Kentucky, Lexington, KY.
David W FardoCollege of Public Health, University of Kentucky, Lexington, KY.
James K HartsfieldCollege of Dentistry, University of Kentucky, Lexington, KY ; College of Medicine, University of Kentucky, Lexington, KY.
Xiuhua DingCollege of Public Health, University of Kentucky, Lexington, KY.
G Thomas KluemperCollege of Dentistry, University of Kentucky, Lexington, KY.
University of Kentucky · US

Funding

UKY DENTAL COBRE: POLYBACTERIAL PERIODONTITIS: N-3 PUFA AND ANTIOXIDANTSP20RR020145 · NCRR · UNIVERSITY OF KENTUCKY · PI EBERSOLE, JEFFREY L · 2004 to 2011
$18.3M
Statistical Genetics Methods for Mixed PathologiesK25AG043546 · NIA · UNIVERSITY OF KENTUCKY · PI FARDO, DAVID WILLIAM · 2013 to 2015
$445k
NCRR NIH HHS P20RR020145
6 · The paper itself

Abstract

STUDY

objectivesThis case-control study investigated whether variations within the APOE-ε gene were associated with having a convex facial profile (skeletal Class II) compared to exhibiting a straight or concave facial profile (Class I or Class III) among patients with obstructive sleep apnea (OSA). Associations between the apnea-hypopnea index (AHI) and body mass index (BMI) scores for these OSA patients were also examined in the context of facial profile.

methodOSA patients with an AHI ≥ 15 were recruited from a sleep clinic and classified by facial and dental occlusal relationships based on a profile facial analysis, lateral photographs, and dental examination. Saliva was collected as a source of DNA. The APOE-ε1-4 allele-defining single nucleotide polymorphisms (SNPs) rs429358 and rs7412 were genotyped. A χ(2) analysis was used to assess Hardy-Weinberg equilibrium and for association analysis (significance at p < 0.05). ANOVA and Fisher exact test were also used.

resultSeventy-six Caucasian OSA patients participated in the study-25 Class II cases and 51 non-Class II cases. There was no association of the APOE-ε4 allele with facial profile among these OSA patients. Class II OSA patients had significantly lower BMIs (30.7 ± 5.78) than Class I (37.3 ± 6.14) or Class III (37.8 ± 6.17) patients (p < 0.001), although there was no statistical difference in AHI for Class II patients compared with other groups.

conclusionOSA patients with Class II convex profile were more likely to have a lower BMI than those in other skeletal groups. In fact 20% of them were not obese, suggesting that a Class II convex profile may influence or be associated with OSA development independent of BMI.

Indexed as

Body Mass IndexAllelesApolipoprotein E4Case-Control StudiesFacial BonesGenotypeHumansMaleMalocclusionMiddle AgedPolymorphism, Single NucleotideRisk FactorsSleep Apnea, ObstructiveSleep Apnea SyndromesApolipoprotein E4AHIAPOE-εBMIfacial profileObstructive sleep apneaskeletal malocclusion

Identifiers

PMID24733985
PMCPMC3960382
OpenAlexW2076882604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.