SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2014
Blood pressure improvement with continuous positive airway pressure is independent of obstructive sleep apnea severity.
Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Tirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial.Nature medicine · 2026Trial
- Socioeconomic status impacts blood pressure response to positive airway pressure treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Trial
- Trial
- Real-world generalizability of sleep apnea-related polysomnographic metrics and their associations with clinical comorbidities.Annals of the American Thoracic Society · 2026Article
- Cardiovascular effects of obstructive sleep apnoea and effects of continuous positive airway pressure therapy: evidence from different study models.ERJ open research · 2025Review
- Nocturia and obstructive sleep apnoea.Nature reviews. Urology · 2024Review
- Potential Therapeutic Targets in Obesity, Sleep Apnea, Diabetes, and Fatty Liver Disease.Journal of clinical medicine · 2024Review
- Loop Gain as a Predictor of Blood Pressure Response in Patients Treated for Obstructive Sleep Apnea: Secondary Analysis of a Clinical Trial.Annals of the American Thoracic Society · 2024Article
- Blood pressure control in hypertensive sleep apnoea patients of the European Sleep Apnea Database cohort - effects of positive airway pressure and antihypertensive medication.European heart journal open · 2023Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Transoral awake state neuromuscular electrical stimulation therapy for mild obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2023Article
- The effect of CPAP therapy on heart rate variability in patients with obstructive sleep apnea.Sleep and biological rhythms · 2023Article
- Review
- Positive Airway Pressure Therapy Adherence with Mask Resupply: A Propensity-Matched Analysis.Journal of clinical medicine · 2021Article
- Practice Recommendations for Diagnosis and Treatment of the Most Common Forms of Secondary Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020Review
- Why do we sometimes ignore the chief complaint in patients evaluated for obstructive sleep apnea?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Severe obstructive sleep apnea is associated with significant coronary artery plaque burden independent of traditional cardiovascular risk factors.The international journal of cardiovascular imaging · 2020Article
- Oral Appliance Therapy for Obstructive Sleep Apnoea: State of the Art.Journal of clinical medicine · 2019Review
- The Potential Role of Obstructive Sleep Apnoea in Refractory Hypertension.Current hypertension reports · 2019Review
- Cardiovascular outcomes of continuous positive airway pressure therapy for obstructive sleep apnea.Journal of thoracic disease · 2018Review
Corrections and comments
- Erratum issuedBarandiarán, Felipe Aizpuru [corrected to Aizpuru, Felipe]
Authors and funding
10 authors.
Funding
Abstract
STUDY
objectivesWe sought to perform a patient-level meta-analysis using the individual patient data of the trials identified in our previous study-level meta-analysis investigating the effect of positive airway pressure (PAP) treatment for obstructive sleep apnea (OSA) on blood pressure (BP).
designPatient-level meta-analysis.
settingN/A.
participants968 adult OSA subjects without major comorbidities drawn from eight randomized controlled trials.
interventionsTherapeutic PAP versus non-therapeutic control conditions (sham-PAP, pill placebo or standard care) over at least one week. MEASUREMENTS AND
resultsThe mean reductions in BP between PAP and non-therapeutic control arms were -2.27 mm Hg (95% CI -4.01 to -0.54) for systolic BP and -1.78 mm Hg (95% CI -2.99 to -0.58) for diastolic BP. The presence of uncontrolled hypertension at baseline was significantly associated with a reduction in systolic BP of 7.1 mm Hg and diastolic BP of 4.3 mm Hg after controlling for OSA severity (apnea-hypopnea index, Epworth Sleepiness Scale score, PAP level), patient demographics (age, gender, body mass index, use of antihypertensive medication/s), and measures of PAP efficacy (PAP adherence and treatment duration).
conclusionsOSA patients with uncontrolled hypertension are likely to gain the largest benefit from PAP in terms of a substantial reduction in BP, even after controlling for disease severity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.