Evidence map›Paper›PMID 24733978›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2014

Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton Health Study cohort.

Nathaniel S Marshall, Keith K H Wong, Stewart R J Cullen, Matthew W Knuiman, Ronald R Grunstein

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 255 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
255citing papers in PubMed, 17 pooled it
24.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06372847 narecruitingnot on this mapstarted 2025, after this paper: background citation

Assessment of the Effect of Hypoglossal Nerve Stimulation Therapy on the Site of Collapse During DISE

TypeinterventionalSponsorUniversity Hospital, AntwerpRan2025 to 2028Enrolled58ConditionsObstructive Sleep ApneaArmsHypoglossal nerve stimulation implant, Polysomnography, Drug-induced sleep endoscopy (DISE)
NCT07337239 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Assessment of the Effect of Hypoglossal Nerve Stimulation Therapy on Upper Airway Collapsibility During Drug-induced Sleep Endoscopy

TypeinterventionalSponsorUniversity Hospital, AntwerpRan2026 to 2027Enrolled21ConditionsObstructive Sleep ApneaArmsAdditional measurements during clinical standard follow-up drug-induced sleep endoscopy (DISE)
3 · Its place in the literature

Who cites it

255 citing papers in PubMed, 17 syntheses or guidelines pooled it, 506 citations in OpenAlex.

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  8. Validation of the STOP questionnaire as a screening tool for OSA among different populations: a systematic review and meta-regression analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
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  9. Association of obstructive sleep apnea and nocturnal hypoxemia with all-cancer incidence and mortality: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
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  12. Sleep Disorders in Cancer-A Systematic Review.International journal of environmental research and public health · 2021
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  17. Management of Obstructive Sleep Apnea in Commercial Motor Vehicle Operators: Recommendations of the AASM Sleep and Transportation Safety Awareness Task Force.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017
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195 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Nathaniel S MarshallNHMRC Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia ; Sydney Nursing School, University of Sydney, Sydney, Australia.
Keith K H WongNHMRC Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia ; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia.
Stewart R J CullenWestern Australian Sleep Disorders Research Institute, Perth, Australia.
Matthew W KnuimanSchool of Population Health, University of Western Australia, Perth, Australia.
Ronald R GrunsteinNHMRC Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia ; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia.
Royal Prince Alfred Hospital · AUThe University of Sydney · AUThe University of Western Australia · AUWest Australian Sleep Disorders Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo ascertain whether objectively measured obstructive sleep apnea (OSA) independently increases the risk of all cause death, cardiovascular disease (CVD), coronary heart disease (CHD), stroke or cancer.

designCommunity-based cohort. SETTING AND

participants400 residents of the Western Australian town of Busselton. MEASURES: OSA severity was quantified via the respiratory disturbance index (RDI) as measured by a single night recording in November-December 1990 using the MESAM IV device, along with a range of other risk factors. Follow-up for deaths and hospitalizations was ascertained via record linkage to the end of 2010.

resultsWe had follow-up data in 397 people and then removed those with a previous stroke (n = 4) from the mortality/ CVD/CHD/stroke analyses and those with cancer history from the cancer analyses (n = 7). There were 77 deaths, 103 cardiovascular events (31 strokes, 59 CHD) and 125 incident cases of cancer (39 cancer fatalities) during 20 years follow-up. In fully adjusted models, moderate-severe OSA was significantly associated with all-cause mortality (HR = 4.2; 95% CI 1.9, 9.2), cancer mortality (3.4; 1.1, 10.2), incident cancer (2.5; 1.2, 5.0), and stroke (3.7; 1.2, 11.8), but not significantly with CVD (1.9; 0.75, 4.6) or CHD incidence (1.1; 0.24, 4.6). Mild sleep apnea was associated with a halving in mortality (0.5; 0.27, 0.99), but no other outcome, after control for leading risk factors.

conclusionsModerate-to-severe sleep apnea is independently associated with a large increased risk of all-cause mortality, incident stroke, and cancer incidence and mortality in this community-based sample.

Indexed as

AdultAgedCardiovascular DiseasesCoronary DiseaseFollow-Up StudiesHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedNeoplasmsRisk FactorsSeverity of Illness IndexSleep Apnea, ObstructiveStrokeWestern Australiacoronary artery diseasemelanomaSleep disordered breathing

Identifiers

PMID24733978
PMCPMC3960375
OpenAlexW2042958005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.