ReviewMediators of inflammation2014
Importins and exportins regulating allergic immune responses.
Review in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Functional Changes Associated With the Subcellular Localization of the Nuclear Receptor NR4A1.Biochemistry research international · 2025Review
- Karyopherins in the Remodeling of Extracellular Matrix: Implications in Tendon Injury.Journal of orthopaedics and sports medicine · 2023Article
- Importin β1 regulates cell growth and survival during adult T cell leukemia/lymphoma therapy.Investigational new drugs · 2021Article
- Article
- MiR-101 relates to chronic peripheral neuropathic pain through targeting KPNB1 and regulating NF-κB signaling.The Kaohsiung journal of medical sciences · 2019Article
- RNA Biology Provides New Therapeutic Targets for Human Disease.Frontiers in genetics · 2019Review
- Nuclear export of ubiquitinated proteins via the UBIN-POST system.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells.Oncotarget · 2017Article
- KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells.Oncotarget · 2017Article
- Chloride intracellular channel proteins respond to heat stress in Caenorhabditis elegans.PloS one · 2017Article
- Article
- Vitamin D Deficiency Accelerates Coronary Artery Disease Progression in Swine.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.Nature neuroscience · 2015Article
- Vitamin D regulating TGF-β induced epithelial-mesenchymal transition.Respiratory research · 2014Article
- Key mediators in the immunopathogenesis of allergic asthma.International immunopharmacology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nucleocytoplasmic shuttling of macromolecules is a well-controlled process involving importins and exportins. These karyopherins recognize and bind to receptor-mediated intracellular signals through specific signal sequences that are present on cargo proteins and transport into and out of the nucleus through nuclear pore complexes. Nuclear localization signals (NLS) present on cargo molecules to be imported while nuclear export signals (NES) on the molecules to be exported are recognized by importins and exportins, respectively. The classical NLS are found on many transcription factors and molecules that are involved in the pathogenesis of allergic diseases. In addition, several immune modulators, including corticosteroids and vitamin D, elicit their cellular responses by regulating the expression and activity of importin molecules. In this review article, we provide a comprehensive list of importin and exportin molecules and their specific cargo that shuttled between cytoplasm and the nucleus. We also critically review the role and regulation of specific importin and exportin involved in the transport of activated transcription factors in allergic diseases, the underlying molecular mechanisms, and the potential target sites for developing better therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.