ArticleProceedings of the National Academy of Sciences of the United States of America2014
Defining modulatory inputs into CNS neuronal subclasses by functional pharmacological profiling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Comparative Ion Channel Transcriptomes of NK1R and Somatostatin Neurons in the PreBötzinger Complex of the Ventrolateral Medulla.Molecular neurobiology · 2026Article
- Elucidation of Medusozoan (Jellyfish) Venom Constituent Activities Using Constellation Pharmacology.Toxins · 2024Article
- Molecular characterization of frog vocal neurons using constellation pharmacology.Journal of neurophysiology · 2020Article
- An integrative approach to the facile functional classification of dorsal root ganglion neuronal subclasses.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Respiratory rhythm generation: triple oscillator hypothesis.F1000Research · 2017Review
- Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives.Current opinion in neurobiology · 2016Review
- Classifying neuronal subclasses of the cerebellum through constellation pharmacology.Journal of neurophysiology · 2016Article
- Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom.Journal of proteomics · 2015Article
- Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency.PloS one · 2015Article
- Constellation pharmacology: a new paradigm for drug discovery.Annual review of pharmacology and toxicology · 2015Review
- A family of excitatory peptide toxins from venomous crassispirine snails: using Constellation Pharmacology to assess bioactivity.Toxicon : official journal of the International Society on Toxinology · 2014Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Previously we defined neuronal subclasses within the mouse peripheral nervous system using an experimental strategy called "constellation pharmacology." Here we demonstrate the broad applicability of constellation pharmacology by extending it to the CNS and specifically to the ventral respiratory column (VRC) of mouse brainstem, a region containing the neuronal network controlling respiratory rhythm. Analysis of dissociated cells from this locus revealed three major cell classes, each encompassing multiple subclasses. We broadly analyzed the combinations (constellations) of receptors and ion channels expressed within VRC cell classes and subclasses. These were strikingly different from the constellations of receptors and ion channels found in subclasses of peripheral neurons from mouse dorsal root ganglia. Within the VRC cell population, a subset of dissociated neurons responded to substance P, putatively corresponding to inspiratory pre-Bötzinger complex (preBötC) neurons. Using constellation pharmacology, we found that these substance P-responsive neurons also responded to histamine, and about half responded to bradykinin. Electrophysiological studies conducted in brainstem slices confirmed that preBötC neurons responsive to substance P exhibited similar responsiveness to bradykinin and histamine. The results demonstrate the predictive utility of constellation pharmacology for defining modulatory inputs into specific neuronal subclasses within central neuronal networks.
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