ArticleProceedings of the National Academy of Sciences of the United States of America2014
Avirulent strains of Toxoplasma gondii infect macrophages by active invasion from the phagosome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
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- Toxoplasma calcium-dependent protein kinases 3 mediates M1 macrophage polarization by targeting host Arginase-1.Parasites & vectors · 2025Article
- Dual single-cell and bulk RNA sequencing reveal transcriptional profiles underlying heterogenous host-parasite interactions in human peripheral blood mononuclear cells.Frontiers in immunology · 2025Article
- The GPI sidechain ofmBio · 2024Article
- Early immune response toFrontiers in cellular and infection microbiology · 2024Article
- Human neutrophil extracellular traps do not impairFrontiers in immunology · 2023Article
- Effects of Ovine Monocyte-Derived Macrophage Infection by Recently IsolatedAnimals : an open access journal from MDPI · 2022Article
- Exploiting the Macrophage Production of IL-12 in Improvement of Vaccine Development againstVaccines · 2022Review
- Seroprevalence of Specific Antibodies toAnimals : an open access journal from MDPI · 2022Article
- A Role for Basigin in Toxoplasma gondii Infection.Infection and immunity · 2022Article
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- Cutting Edge: CD36 Mediates Phagocyte Tropism and Avirulence ofJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Dehydroepiandrosterone Effect onMicroorganisms · 2021Article
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- A Protective and Pathogenic Role for Complement During AcuteFrontiers in cellular and infection microbiology · 2021Review
- Single-cell RNA-seq reveals CD16Scientific reports · 2020Article
- Extracellular Traps Released by Neutrophils from Cats are Detrimental toMicroorganisms · 2020Article
- Toxoplasma GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11.PLoS pathogens · 2020Article
- CD209 C-Type Lectins Promote Host Invasion, Dissemination, and Infection ofFrontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Unlike most intracellular pathogens that gain access into host cells through endocytic pathways, Toxoplasma gondii initiates infection at the cell surface by active penetration through a moving junction and subsequent formation of a parasitophorous vacuole. Here, we describe a noncanonical pathway for T. gondii infection of macrophages, in which parasites are initially internalized through phagocytosis, and then actively invade from within a phagosomal compartment to form a parasitophorous vacuole. This phagosome to vacuole invasion (PTVI) pathway may represent an intermediary link between the endocytic and the penetrative routes for host cell entry by intracellular pathogens. The PTVI pathway is preferentially used by avirulent strains of T. gondii and confers an infectious advantage over virulent strains for macrophage tropism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.