ArticleProceedings of the National Academy of Sciences of the United States of America2014
Sea star tenacity mediated by a protein that fragments, then aggregates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 90 citations in OpenAlex.
- Tube feet dynamics drive adaptation in sea star locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Recombinant Proteins: A Molecular Tool to Understand Marine Adhesion and to Advance Biomaterials.Advanced healthcare materials · 2026Review
- Amyloid-like Structures in Marine Adhesive Proteins.Marine drugs · 2025Review
- Starfish-inspired tube feet for temporary and switchable underwater adhesion and transportation.Science advances · 2025Article
- Research Progress on Starfish Outbreaks and Their Prevention and Utilization: Lessons from Northern China.Biology · 2024Review
- Recurrent evolution of adhesive defence systems in amphibians by parallel shifts in gene expression.Nature communications · 2024Article
- Self-assembly of a barnacle cement protein into intertwined amyloid fibres and determination of their adhesive and viscoelastic properties.Journal of the Royal Society, Interface · 2023Article
- Glycoproteins Involved in Sea Urchin Temporary Adhesion.Marine drugs · 2023Article
- Comparative Genomics Reveals Evolutionary Drivers of Sessile Life and Left-right Shell Asymmetry in Bivalves.Genomics, proteomics & bioinformatics · 2022Article
- The Involvement of Cell-Type-Specific Glycans inBiomimetics (Basel, Switzerland) · 2022Article
- In the footsteps of sea stars: deciphering the catalogue of proteins involved in underwater temporary adhesion.Open biology · 2022Article
- Sticking Together an Updated Model for Temporary Adhesion.Marine drugs · 2022Article
- Biomaterials and Bioactive Natural Products from Marine Invertebrates: From Basic Research to Innovative Applications.Marine drugs · 2022Review
- Decoding the byssus fabrication by spatiotemporal secretome analysis of scallop foot.Computational and structural biotechnology journal · 2022Article
- (Un)expected Similarity of the Temporary Adhesive Systems of Marine, Brackish, and Freshwater Flatworms.International journal of molecular sciences · 2021Article
- Disentangling the Roles of Functional Domains in the Aggregation and Adsorption of the Multimodular Sea Star Adhesive Protein Sfp1.Marine biotechnology (New York, N.Y.) · 2021Article
- Sea stars generate downforce to stay attached to surfaces.Scientific reports · 2021Article
- Continuous High-Throughput Fabrication of Architected Micromaterials via In-Air Photopolymerization.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Molecular insights into the powerful mucus-based adhesion of limpets (Open biology · 2020Article
- Enhancement performance of application mussel-biomimetic adhesive primer for dentin adhesives.RSC advances · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sea stars adhere firmly but temporarily to various substrata as a result of underwater efficient adhesive secretions released by their tube feet. Previous studies showed that this material is mainly made up of proteins, which play a key role in its adhesiveness and cohesiveness. Recently, we solubilized the majority of these proteins and obtained 43 de novo-generated peptide sequences by tandem MS. Here, one of these sequences served to recover the full-length sequence of Sea star footprint protein 1 (Sfp1), by RT-PCR and tube foot transcriptome analysis. Sfp1, a large protein of 3,853 aa, is the second most abundant constituent of the secreted adhesive. By using MS and Western blot analyses, we showed that Sfp1 is translated from a single mRNA and then cleaved into four subunits linked together by disulphide bridges in tube foot adhesive cells. The four subunits display specific protein-, carbohydrate-, and metal-binding domains. Immunohistochemistry and immunocytochemistry located Sfp1 in granules stockpiled by one of the two types of adhesive cells responsible for the secretion of the adhesive material. We also demonstrated that Sfp1 makes up the structural scaffold of the adhesive footprint that remains on the substratum after tube foot detachment. Taken together, the results suggest that Sfp1 is a major structural protein involved in footprint cohesion and possibly in adhesive interactions with the tube foot surface. In recombinant form, it could be used for the design of novel sea star-inspired biomaterials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.