ArticleProceedings of the National Academy of Sciences of the United States of America2014
Rescuing US biomedical research from its systemic flaws.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 313 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
313 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Prevalence and severity of mental health problems in early-career researchers: a systematic review and meta-analysis.Nature human behaviour · 2026Pooled it
- The characteristics of early-stage research into human genes are substantially different from subsequent research.PLoS biology · 2022Pooled it
- Systematic review and meta-analysis of depression, anxiety, and suicidal ideation among Ph.D. students.Scientific reports · 2021Pooled it
- Guideline
- NIH funding and the pursuit of edge science.Proceedings of the National Academy of Sciences of the United States of America · 2020Pooled it
- Co-reviewing and ghostwriting by early-career researchers in the peer review of manuscripts.eLife · 2019Pooled it
- Pooled it
- Article
- Crisis as Catalyst: The Future of the NIH Driving Scientific Discovery.The Journal of infectious diseases · 2026Article
- The SciLifeLab PULSE entrepreneurial model: accelerating drug discovery by bridging academia and industry.Nature biotechnology · 2026Article
- How Mentoring Networks Shape Early-Career Grant Success: Evidence from NIH K-awardees.bioRxiv : the preprint server for biology · 2026Article
- Overwhelmed and Unnoticed-Burnout in Biomedical Scientists: A Narrative Review.International journal of environmental research and public health · 2026Review
- How the 2025 NIH grant terminations varied by researchers' demographic groups.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Article
- The success-failure inversion in modern medicine.Frontiers in public health · 2026Article
- Article
- Most researchers would receive more recognition if assessed by article-level metrics than by journal-level metrics.PLoS biology · 2025Article
- Lottery before peer review is associated with increased female representation and reduced estimated economic cost in a German funding line.Nature communications · 2025Article
- Implementation of Clinical Pharmacy Services in Primary Health Care: A Scoping Review.Journal of evaluation in clinical practice · 2025Article
253 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The long-held but erroneous assumption of never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession--and making it difficult for seasoned investigators to produce their best work. This is a recipe for long-term decline, and the problems cannot be solved with simplistic approaches. Instead, it is time to confront the dangers at hand and rethink some fundamental features of the US biomedical research ecosystem.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.