ArticleProceedings of the National Academy of Sciences of the United States of America2014
Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- The proteomic landscape and temporal dynamics of human and mouse gastruloid development.Nature cell biology · 2026Article
- AI-powered simulation-based inference of a genuinely spatial-stochastic gene regulation model of early mouse embryogenesis.PLoS computational biology · 2024Article
- Identification of neutrophil extracellular trap-related biomarkers in non-alcoholic fatty liver disease through machine learning and single-cell analysis.Scientific reports · 2024Article
- BRF1 promotes the odontogenic differentiation of dental pulp stem cells in pulpitis by inducing autophagy.Heliyon · 2024Article
- Conflicting Roles of ZFP36L1 in Regulating the Progression of Muscle Invasive Bladder Cancer.Frontiers in molecular biosciences · 2022Article
- ZFP36L2 Role in Thyroid Functionality.International journal of molecular sciences · 2021Article
- Article
- BRF1 ameliorates LPS-induced inflammation through autophagy crosstalking with MAPK/ERK signaling.Genes & diseases · 2018Article
- Yeast Cth2 protein represses the translation of ARE-containing mRNAs in response to iron deficiency.PLoS genetics · 2018Article
- X-chromosome dosage as a modulator of pluripotency, signalling and differentiation?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells.PloS one · 2017Article
- LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.Nature cell biology · 2017Article
- mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.Nature cell biology · 2015Article
- Regulation of pluripotency by RNA binding proteins.Cell stem cell · 2014Review
- Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
AU-rich element mRNA-binding proteins (AUBPs) are key regulators of development, but how they are controlled and what functional roles they play depends on cellular context. Here, we show that Brf1 (zfp36l1), an AUBP from the Zfp36 protein family, operates downstream of FGF/Erk MAP kinase signaling to regulate pluripotency and cell fate decision making in mouse embryonic stem cells (mESCs). FGF/Erk MAP kinase signaling up-regulates Brf1, which disrupts the expression of core pluripotency-associated genes and attenuates mESC self-renewal without inducing differentiation. These regulatory effects are mediated by rapid and direct destabilization of Brf1 targets, such as Nanog mRNA. Enhancing Brf1 expression does not compromise mESC pluripotency but does preferentially regulate mesendoderm commitment during differentiation, accelerating the expression of primitive streak markers. Together, these studies demonstrate that FGF signals use targeted mRNA degradation by Brf1 to enable rapid posttranscriptional control of gene expression in mESCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.