ArticlePlant physiology2014
Distinct Copy Number, Coding Sequence, and Locus Methylation Patterns Underlie Rhg1-Mediated Soybean Resistance to Soybean Cyst Nematode.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
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Who cites it
83 citing papers in PubMed.
- AATRhg1 is a tonoplast protein that alters amino acid, metabolic, and defense responses and nematode resistance.Plant physiology · 2026Article
- Allele variation at the Rdm3 locus conferring resistance to soybean southern stem canker.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Time- and Genotype-Dependent Root-Transcriptomic Responses of Soybean to Combined Soybean Aphid and Soybean Cyst Nematode Infestation.Plants (Basel, Switzerland) · 2026Article
- A Highly Conserved SNARE-Associated Protein Enhances Plant Immunity by Regulating Vesicle Trafficking.Plant biotechnology journal · 2026Article
- Genome-wide association study of soybean germplasm derived from modern Canadian and Chinese soybean cultivars to identify novel genes conferring soybean cyst nematode resistance.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Genome-wide association study and molecular marker development for resistance to soybean cyst nematode in soybean.The plant genome · 2025Article
- Soybean Cyst Nematode-Resistant Protein AATPlant direct · 2025Article
- The AP2/ERF transcription factor GmTINY mediates ethylene regulation of Rhg1-conferred resistance against soybean cyst nematode.Plant communications · 2025Article
- Genetic diversity, population structure in a historical panel of Brazilian soybean cultivars.PloS one · 2025Article
- Dynamic transcriptomic responses to soybean cyst nematode infection in soybean genotypes with contrasting resistance profiles.Frontiers in plant science · 2025Article
- Allele-tagged TaqManMolecular biology reports · 2024Article
- Impact of Rhg1 copy number variation on a soybean cyst nematode resistance transcriptional network.G3 (Bethesda, Md.) · 2024Article
- Copy number variations at theFrontiers in plant science · 2024Article
- No Pairwise Interactions of GmSNAP18, GmSHMT08 and AtPR1 with SuppressedPlants (Basel, Switzerland) · 2023Article
- Soybean-SCN Battle: Novel Insight into Soybean's Defense Strategies againstInternational journal of molecular sciences · 2023Article
- Genetic Architecture of Salt Tolerance in Cowpea (International journal of molecular sciences · 2023Article
- Soybean transporter AAT Rhg1 abundance increases along the nematode migration path and impacts vesiculation and ROS.Plant physiology · 2023Article
- The elite variations in germplasms for soybean breeding.Molecular breeding : new strategies in plant improvement · 2023Article
- Mapping of a soybean rust resistance in PI 594756 at theMolecular breeding : new strategies in plant improvement · 2023Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copy number variation of kilobase-scale genomic DNA segments, beyond presence/absence polymorphisms, can be an important driver of adaptive traits. Resistance to Heterodera glycines (Rhg1) is a widely utilized quantitative trait locus that makes the strongest known contribution to resistance against soybean cyst nematode (SCN), Heterodera glycines, the most damaging pathogen of soybean (Glycine max). Rhg1 was recently discovered to be a complex locus at which resistance-conferring haplotypes carry up to 10 tandem repeat copies of a 31-kb DNA segment, and three disparate genes present on each repeat contribute to SCN resistance. Here, we use whole-genome sequencing, fiber-FISH (fluorescence in situ hybridization), and other methods to discover the genetic variation at Rhg1 across 41 diverse soybean accessions. Based on copy number variation, transcript abundance, nucleic acid polymorphisms, and differentially methylated DNA regions, we find that SCN resistance is associated with multicopy Rhg1 haplotypes that form two distinct groups. The tested high-copy-number Rhg1 accessions, including plant introduction (PI) 88788, contain a flexible number of copies (seven to 10) of the 31-kb Rhg1 repeat. The identified low-copy-number Rhg1 group, including PI 548402 (Peking) and PI 437654, contains three copies of the Rhg1 repeat and a newly identified allele of Glyma18g02590 (a predicted α-SNAP [α-soluble N-ethylmaleimide-sensitive factor attachment protein]). There is strong evidence for a shared origin of the two resistance-conferring multicopy Rhg1 groups and subsequent independent evolution. Differentially methylated DNA regions also were identified within Rhg1 that correlate with SCN resistance. These data provide insights into copy number variation of multigene segments, using as the example a disease resistance trait of high economic importance.
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Registered trials
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