ArticleJournal of biomedical materials research. Part A2015
Role of α2β1 integrins in mediating cell shape on microtextured titanium surfaces.
Article in Journal of biomedical materials research. Part A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Bioceramics Based on Li-Modified Bioactive Glasses for Bone Tissue Regeneration.Materials (Basel, Switzerland) · 2026Article
- Bone Marrow Stromal Cells Generate a Pro-Healing Inflammasome When Cultured on Titanium-Aluminum-Vanadium Surfaces with Microscale/Nanoscale Structural Features.Biomimetics (Basel, Switzerland) · 2025Article
- Influence of the Surface Topography of Titanium Dental Implants on the Behavior of Human Amniotic Stem Cells.International journal of molecular sciences · 2024Article
- Wnt16 Increases Bone-to-Implant Contact in an Osteopenic Rat Model by Increasing Proliferation and Regulating the Differentiation of Bone Marrow Stromal Cells.Annals of biomedical engineering · 2024Article
- CD4Acta biomaterialia · 2024Article
- An overview of 3D printed metal implants in orthopedic applications: Present and future perspectives.Heliyon · 2023Review
- Antibacterial and anti-inflammatory effects of PGLa-loaded TiOFrontiers in chemistry · 2023Article
- Micropattern Silk Fibroin Film Facilitates Tendon RepairStem cells international · 2023Article
- Article
- Growth factors produced by bone marrow stromal cells on nanoroughened titanium-aluminum-vanadium surfaces program distal MSCs into osteoblasts via BMP2 signaling.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Benchtop plasma treatment of titanium surfaces enhances cell response.Dental materials : official publication of the Academy of Dental Materials · 2021Article
- Review on material parameters to enhance bone cell function in vitro and in vivo.Biochemical Society transactions · 2020Review
- Article
- Hot isostatic pressure treatment of 3D printed Ti6Al4V alters surface modifications and cellular response.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Osteoblasts grown on microroughened titanium surfaces regulate angiogenic growth factor production through specific integrin receptors.Acta biomaterialia · 2019Article
- Disproportionate Effect of Sub-Micron Topography on Osteoconductive Capability of Titanium.International journal of molecular sciences · 2019Article
- Advances in Porous Scaffold Design for Bone and Cartilage Tissue Engineering and Regeneration.Tissue engineering. Part B, Reviews · 2019Review
- Human osteoblasts exhibit sexual dimorphism in their response to estrogen on microstructured titanium surfaces.Biology of sex differences · 2018Article
- Role of Wnt11 during Osteogenic Differentiation of Human Mesenchymal Stem Cells on Microstructured Titanium Surfaces.Scientific reports · 2018Article
- Imaging analysis of the interface between osteoblasts and microrough surfaces of laser-sintered titanium alloy constructs.Journal of microscopy · 2018Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
Abstract
Surface microroughness plays an important role in determining osteoblast behavior on titanium. Previous studies have shown that osteoblast differentiation on microtextured titanium substrates is dependent on alpha-2 beta-1 (α2β1) integrin signaling. This study used focused ion beam milling and scanning electron microscopy, combined with three-dimensional image reconstruction, to investigate early interactions of individual cells with their substrate and the role of integrin α2β1 in determining cell shape. MG63 osteoblast-like cells on sand blasted/acid etched (SLA) Ti surfaces after 3 days of culturing indicated decreased cell number, increased cell differentiation, and increased expression of mRNA levels for α1, α2, αV, and β1 integrin subunits compared to cells on smooth Ti (PT) surfaces. α2 or β1 silenced cells exhibited increased cell number and decreased differentiation on SLA compared to wild-type cells. Wild-type cells on SLA possessed an elongated morphology with reduced cell area, increased cell thickness, and more apparent contact points. Cells on PT exhibited greater spreading and were relatively flat. Silenced cells possessed a morphology and phenotype similar to wild-type cells grown on PT. These observations indicate that surface microroughness affects cell response via α2β1 integrin signaling, resulting in a cell shape that promotes osteoblastic differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.