ReviewNeuroscience bulletin2014
Disrupted structural and functional brain connectomes in mild cognitive impairment and Alzheimer's disease.
Review in Neuroscience bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04000984 (Investigating the Beneficial Effects of Mindfulness-based Training on Neuropsychological Outcomes in Mild Cognitive Impairment), which is not on this map. Cited by 93 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Beneficial Effects of Mindfulness-based Training on Neuropsychological Outcomes in Mild Cognitive Impairment
Who cites it
93 citing papers in PubMed, 1 synthesis or guideline pooled it, 171 citations in OpenAlex.
- Application of Graph Theory for Identifying Connectivity Patterns in Human Brain Networks: A Systematic Review.Frontiers in neuroscience · 2019Pooled it
- Increased segregation of structural brain networks underpins enhanced broad cognitive abilities of cognitive training.Human brain mapping · 2021Trial
- Altered Network Topology in Patients with Primary Brain Tumors After Fractionated Radiotherapy.Brain connectivity · 2017Trial
- The Impact of Denoising Approaches on the Relationship Between Alzheimer's Disease Diagnostic Status and Network Topology Measures.Human brain mapping · 2026Article
- Dissociable, species-specific impact of Aβ on static and dynamic functional connectomes.bioRxiv : the preprint server for biology · 2026Article
- Disentangling global atrophy burden from local structural patterns reveals clinically relevant heterogeneity in mild cognitive impairment.Research square · 2026Article
- Moderating role of executive function in the relationship between specific white matter changes and long-term delayed recall in aMCI patients.Alzheimer's research & therapy · 2026Article
- Spatiotemporal profiling of functional network overlapping modules in Alzheimer's disease.Network neuroscience (Cambridge, Mass.) · 2026Article
- Neural compensation in persons with HIV and marijuana use: Insights from a reorganized DMN.Network neuroscience (Cambridge, Mass.) · 2026Article
- Compound Congrong Yizhi capsule partially remodels the fronto-retrosplenial-hippocampal memory circuit in vascular dementia rats.Frontiers in neurology · 2026Article
- The Human Claustrum Activates Across Multiple Cognitive Control Tasks.The European journal of neuroscience · 2025Article
- Image complexity-based fMRI-BOLD visual network categorization across visual datasets using topological descriptors and deep-hybrid learning.Scientific reports · 2025Article
- Semantic locality-aware biclustering for brain functional network connectivity.Scientific reports · 2025Article
- Topological and geometric signatures of brain network dynamics in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Patterns of pathological tau deposition reflect the dynamics of cortical brain activity.Cell reports · 2025Article
- Revealing heterogeneity in mild cognitive impairment based on individualized structural covariance network.Alzheimer's research & therapy · 2025Article
- Structural connectome manifold changes related to body mass index and their associations with eating psychopathology.NeuroImage. Clinical · 2025Article
- Evaluation of the diagnostic efficacy of core biomarkers in cerebrospinal fluid for Alzheimer's disease: a systematic review and meta-analysis.Frontiers in neurology · 2025Review
- Connectome-based prediction of future episodic memory performance for individual amnestic mild cognitive impairment patients.Brain communications · 2025Article
- Network analysis of cognition and function in Alzheimer's disease: a cross-sectional study.Frontiers in psychiatry · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is the most common type of dementia, comprising an estimated 60-80% of all dementia cases. It is clinically characterized by impairments of memory and other cognitive functions. Previous studies have demonstrated that these impairments are associated with abnormal structural and functional connections among brain regions, leading to a disconnection concept of AD. With the advent of a combination of non-invasive neuroimaging (structural magnetic resonance imaging (MRI), diffusion MRI, and functional MRI) and neurophysiological techniques (electroencephalography and magnetoencephalography) with graph theoretical analysis, recent studies have shown that patients with AD and mild cognitive impairment (MCI), the prodromal stage of AD, exhibit disrupted topological organization in large-scale brain networks (i.e., connectomics) and that this disruption is significantly correlated with the decline of cognitive functions. In this review, we summarize the recent progress of brain connectomics in AD and MCI, focusing on the changes in the topological organization of large-scale structural and functional brain networks using graph theoretical approaches. Based on the two different perspectives of information segregation and integration, the literature reviewed here suggests that AD and MCI are associated with disrupted segregation and integration in brain networks. Thus, these connectomics studies open up a new window for understanding the pathophysiological mechanisms of AD and demonstrate the potential to uncover imaging biomarkers for clinical diagnosis and treatment evaluation for this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.