ArticleNeuroscience bulletin2014
Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults.
Article in Neuroscience bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Red-light photobiomodulation improves cognition and neuropsychiatric symptoms in post-stroke cognitive impairment: a randomized trial.Frontiers in neurology · 2025Trial
- Photobiomodulation for Alzheimer's disease: photoelectric coupling effect on attenuating Aβ neurotoxicity.Lasers in medical science · 2023Review
- The potential diagnostic accuracy of urine formaldehyde levels in Alzheimer's disease: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Article
- Systematic evaluation of urinary formic acid as a new potential biomarker for Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
- Effect of ribose-glycated BSA on histone demethylation.Frontiers in genetics · 2022Article
- Urinary Biomarkers for Neurodegenerative Diseases.Experimental neurobiology · 2020Review
- TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.Neurotoxicity research · 2020Article
- Hydrogen Sulfide Inhibits Formaldehyde-Induced Senescence in HT-22 Cells via Upregulation of Leptin Signaling.Neuromolecular medicine · 2019Article
- A rapid and sensitive fluorescence method for detecting urine formaldehyde in patients with Alzheimer's disease.Annals of clinical biochemistry · 2019Article
- Altered Static and Temporal Dynamic Amplitude of Low-Frequency Fluctuations in the Background Network During Working Memory States in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2019Article
- Pyrenyl carbon nanostructures for ultrasensitive measurements of formaldehyde in urine.Analytica chimica acta · 2017Article
- A Sensitive and Rapid Method for Detecting Formaldehyde in Brain Tissues.Analytical cellular pathology (Amsterdam) · 2017Article
- Altered Distant Synchronization of Background Network in Mild Cognitive Impairment during an Executive Function Task.Frontiers in behavioral neuroscience · 2017Article
- Brain Formaldehyde is Related to Water Intake behavior.Aging and disease · 2016Article
- Icariin protects SH-SY5Y cells from formaldehyde-induced injury through suppression of Tau phosphorylation.Chinese journal of integrative medicine · 2016Article
- Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients.Journal of Alzheimer's disease : JAD · 2016Article
- Elevated urine formaldehyde in elderly patients with primary open angle glaucoma.International journal of ophthalmology · 2016Article
- Frequency-Dependent Brain Regional Homogeneity Alterations in Patients with Mild Cognitive Impairment during Working Memory State Relative to Resting State.Frontiers in aging neuroscience · 2016Article
- Article
- BDNF-TrkB pathway mediates neuroprotection of hydrogen sulfide against formaldehyde-induced toxicity to PC12 cells.PloS one · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have shown that the abnormal accumulation of endogenous formaldehyde could be a critical factor in age-related cognitive decline. The aim of this study was to estimate the correlation between uric formaldehyde and general cognitive abilities in a community-based elderly population, and to measure the extent and direction in which the correlation varied with demographic characteristics. Using a double-blind design, formaldehyde in human urine was analyzed by high-performance liquid chromatography (n = 604), and general cognitive abilities were measured using the Montreal Cognitive Assessment (MoCA). Demographic characteristics, in terms of age, gender, residential region, and education were taken into consideration. We found that uric formaldehyde levels were inversely correlated with the MoCA score, and the concentration varied with demographic features: higher odds of a high formaldehyde level occurred among the less educated and those living in old urban or rural areas. In cytological experiments, the level of cellular formaldehyde released into the medium increased as SH-SY5Y and BV2 cells were incubated for three days. Formaldehyde in excess impaired the processes of N2a cells and neurites of primary cultured rat hippocampal cells. However, removal of formaldehyde markedly rescued and regenerated the processes of N2a cells. These results demonstrated a negative correlation between the endogenous formaldehyde and general cognitive abilities. High formaldehyde levels could be a risk factor for cognitive impairment in older adults, and could be developed as a non-invasive marker for detection and monitoring of age-related cognitive impairment.
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Registered trials
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