Evidence map›Paper›PMID 24733643›Full record

GuidelineJournal of neuro-oncology2014

The role of neuropathology in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline.

Daniel J Brat, Timothy Charles Ryken, Steven N Kalkanis, Jeffrey J Olson, AANS/CNS Joint Guidelines Committee

Abstract readPractice GuidelineSystematic Review
PubMed Publisher
In one paragraph

Guideline in Journal of neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel J BratDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA, dbrat@emory.edu.
Timothy Charles Ryken
Steven N Kalkanis
Jeffrey J Olson
AANS/CNS Joint Guidelines Committee

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

question1. What are the most important diagnostic considerations in reporting progressive glioblastoma? TARGET POPULATION: These recommendations apply to adults with progressive glioblastoma RECOMMENDATIONS: LEVEL III: For patients who undergo biopsy or neurosurgical resection at the time of radiologic or clinical progression, it is recommended that the pathologist report the presence and extent of progressive neoplasm as well as the presence and extent of necrosis within the pathologic material examined. Furthermore, to ensure the proper interpretation of progressive glioblastoma, it is recommended that the pathologist take into account the patient's previous diagnosis and treatment, as well as the current clinical and neuroimaging features that have led to a second biopsy or resection. QUESTION: 2. What techniques and ancillary studies are most useful in separating malignant progression from treatment effect? TARGET POPULATION: These recommendations apply to adults with progressive glioblastoma RECOMMENDATIONS: LEVEL III: In the setting of prior radiation and chemotherapy, it is recommended to adhere to strict histologic criteria for microvascular proliferation and necrosis in order to establish a diagnosis of a glioblastoma. Immunohistochemistry and genetic studies are selectively recommended for distinguishing neoplastic cells from atypical reactive cells in progressive glioblastoma.

Indexed as

AdultBrain NeoplasmsCell ProliferationDisease ProgressionEvidence-Based MedicineFrozen SectionsGlioblastomaHumansImmunohistochemistryMolecular Diagnostic TechniquesRadiation Injuries

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.