Evidence map›Paper›PMID 24733634›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2014

Sleep, fatigue, depression, and circadian activity rhythms in women with breast cancer before and after treatment: a 1-year longitudinal study.

Sonia Ancoli-Israel, Lianqi Liu, Michelle Rissling, Loki Natarajan, Ariel B Neikrug, Barton W Palmer, Paul J Mills, Barbara A Parker, Georgia Robins Sadler, Jeanne Maglione

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02954809 (Feasibility of Bright Light Therapy on Fatigue, Sleep and Circadian Activity Rhythms in Lung Cancer Survivors), which is not on this map. Cited by 124 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02954809 nacompletednot on this mapstarted 2016, after this paper: background citation

Feasibility of Bright Light Therapy on Fatigue, Sleep and Circadian Activity Rhythms in Lung Cancer Survivors

TypeinterventionalSponsorState University of New York at BuffaloRan2016 to 2018Enrolled14ConditionsFatigue, Sleep Disturbance, Circadian DysregulationArmsMorning bright light therapy, Dim light
3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Effect of cancer treatment on sleep quality in cancer patients: A systematic review and meta-analysis of Pittsburgh Sleep Quality Index.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  5. Sleep Disorders in Cancer-A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  6. Pooled it
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  9. Integrated psychosocial, sleep, and immunonutritional intervention improves psychological adaptation, sleep disturbance, and inflammatory activation in rectal cancer: a randomized controlled trial.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Trial
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  11. Telehealth cognitive behaviour therapy for the management of sleep disturbance in women with early breast cancer receiving chemotherapy: a feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
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  14. The Effect of Systematic Light Exposure on Sleep in a Mixed Group of Fatigued Cancer Survivors.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018
    Trial
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  20. Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sonia Ancoli-IsraelDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA, sancoliisrael@ucsd.edu.
Lianqi Liu
Michelle Rissling
Loki Natarajan
Ariel B Neikrug
Barton W Palmer
Paul J Mills
Barbara A Parker
Georgia Robins Sadler
Jeanne Maglione

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jing Yang · 1985 to 2026
$124.9M
SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Contributions of sleep/rhythms/fatigue to chemobrainR01CA112035 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANCOLI-ISRAEL, SONIA · 2005 to 2009
$1.8M
FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCERR01CA085264 · NCI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI ANCOLI-ISRAEL, SONIA · 2000 to 2004
$1.4M
NCI NIH HHS CA112035NCI NIH HHS P30 CA023100NCI NIH HHS R01 CA085264NCI NIH HHS R01 CA112035NCRR NIH HHS UL1 RR031980NCRR NIH HHS UL1RR031980NIMH NIH HHS T32 MH019934
6 · The paper itself

Abstract

purposeSleep disturbance, fatigue and depression are common complaints in patients with cancer, and often contribute to worse quality of life (QoL). Circadian activity rhythms (CARs) are often disrupted in cancer patients. These symptoms worsen during treatment, but less is known about their long-term trajectory.

methodsSixty-eight women with stage I-III breast cancer (BC) scheduled to receive ≥4 cycles of chemotherapy, and age-, ethnicity-, and education-matched normal, cancer-free controls (NC) participated. Sleep was measured with actigraphy (nocturnal total sleep time [nocturnal TST] and daytime total nap time [NAPTIME]) and with the Pittsburgh Sleep Quality Index (PSQI); fatigue with the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF); depression with the Center of Epidemiological Studies-Depression (CES-D). CARs were derived from actigraphy. Several measures of QoL were administered. Data were collected at three time points: before (baseline), end of cycle 4 (cycle 4), and 1 year post-chemotherapy (1 year).

resultsCompared to NC, BC had longer NAPTIME, worse sleep quality, more fatigue, more depressive symptoms, more disrupted CARs, and worse QoL at baseline (all p values <0.05). At cycle 4, BC showed worse sleep, increased fatigue, more depressive symptoms, and more disrupted CARs compared to their own baseline levels and to NC (all p values <0.05). By 1 year, BC's fatigue, depressive symptoms, and QoL returned to baseline levels but were still worse than those of NC, while NAPTIME and CARs did not differ from NC's.

conclusionAdditional research is needed to determine if beginning treatment of these symptoms before the start of chemotherapy will minimize symptom severity over time.

Indexed as

Circadian RhythmActigraphyActivities of Daily LivingAdultAgedAged, 80 and overBreast NeoplasmsDepressionFatigueFemaleHumansLongitudinal StudiesMiddle AgedQuality of LifeSleepSleep Wake Disorders

Identifiers

PMID24733634
PMCPMC4119484

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.