Evidence map›Paper›PMID 24733470›Full record

ArticleAntimicrobial agents and chemotherapy2014

Multiplex PCR for identification of two capsular types in epidemic KPC-producing Klebsiella pneumoniae sequence type 258 strains.

Liang Chen, Kalyan D Chavda, Jacqueline Findlay, Gisele Peirano, Katie Hopkins, Johann D D Pitout, Robert A Bonomo, Neil Woodford, Frank R DeLeo, Barry N Kreiswirth

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Differential virulence potential of different clades of multidrug-resistantmedRxiv : the preprint server for health sciences · 2026
    Article
  3. Multidrug-ResistantMicroorganisms · 2024
    Article
  4. Review
  5. Characterization of Phenotypic and Genotypic Traits ofInfection and drug resistance · 2020
    Article
  6. Article
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  11. Article
  12. Article
  13. Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS I and II.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Article
  14. Review
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Liang ChenPublic Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Kalyan D ChavdaPublic Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Jacqueline FindlayAntimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, Public Health England, London, United Kingdom.
Gisele PeiranoDivision of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada Departments of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
Katie HopkinsAntimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, Public Health England, London, United Kingdom.
Johann D D PitoutDivision of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada Departments of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada Departments of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.
Robert A BonomoResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Departments of Medicine, Pharmacology, Molecular Biology, and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA.
Neil WoodfordAntimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, Public Health England, London, United Kingdom.
Frank R DeLeoLaboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Barry N KreiswirthPublic Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA kreiswba@njms.rutgers.edu.
Public Health England · GBRutgers, The State University of New Jersey · USCalgary Laboratory Services · CACase Western Reserve University · USNational Institutes of Health · USUniversity of Calgary · CA

Funding

Basis for Success of Multidrug-Resistant EnterobacteriaceaeZIAAI001195 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DELEO, FRANK · 2014 to 2025
$11.9M
Mechanisms of Staphylococcus aureus virulenceZIAAI001079 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DELEO, FRANK · 2009 to 2025
$11.8M
The molecular basis of the epidemic blaKPC gene KlebsiellaR01AI090155 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KREISWIRTH, BARRY NEAL · 2011 to 2021
$7.2M
Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
Intramural NIH HHSNIAID NIH HHS 1R01AI090155NIAID NIH HHS R01 AI063517NIAID NIH HHS R01AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01AI072219NIAID NIH HHS R01 AI090155
6 · The paper itself

Abstract

We developed a multiplex PCR assay capable of identifying two capsular polysaccharide synthesis sequence types (sequence type 258 [ST258] cps-1 and cps-2) in epidemic Klebsiella pneumoniae ST258 strains. The assay performed with excellent sensitivity (100%) and specificity (100%) for identifying cps types in 60 ST258 K. pneumoniae sequenced isolates. The screening of 419 ST258 clonal isolates revealed a significant association between cps type and K. pneumoniae carbapenemase (KPC) variant: cps-1 is largely associated with KPC-2, while cps-2 is primarily associated with KPC-3.

Indexed as

Anti-Bacterial AgentsBacterial CapsulesBacterial Proteinsbeta-LactamasesCarbapenemsDNA, BacterialDrug Resistance, BacterialHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsMolecular Sequence DataMolecular TypingMultiplex Polymerase Chain ReactionAnti-Bacterial AgentsBacterial Proteinsbeta-lactamase KPC-3, Klebsiella pneumoniaebeta-Lactamasescarbapenemase-2, Klebsiella pneumoniaeCarbapenemsDNA, Bacterial

Identifiers

PMID24733470
PMCPMC4068549
OpenAlexW2076144893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.