ArticleMagnetic resonance in medicine2015
Exchange kinetics by inversion transfer: integrated analysis of the phosphorus metabolite kinetic exchanges in resting human skeletal muscle at 7 T.
Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A 7T MRI Study of Fibular Bone Thickness and Density: Impact of Age, Sex and Body Weight, and Correlation with Bone Marrow Expansion and Muscle Fat Infiltration.Diagnostics (Basel, Switzerland) · 2025Article
- Use ofAging cell · 2023Article
- Phosphates form spectroscopically dark state assemblies in common aqueous solutions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Quantification of creatine kinase reaction rate in mouse hindlimb using phosphorus-31 magnetic resonance spectroscopic fingerprinting.NMR in biomedicine · 2021Article
- A Review of Non-IEEE open journal of engineering in medicine and biology · 2020Article
- ModularMagnetic resonance in medicine · 2019Article
- Rapid and simultaneous measurement of phosphorus metabolite pool size ratio and reaction kinetics of enzymes in vivo.Journal of magnetic resonance imaging : JMRI · 2018Article
- Article
- Assessing tissue metabolism by phosphorous-31 magnetic resonance spectroscopy and imaging: a methodology review.Quantitative imaging in medicine and surgery · 2017Review
- EfficientMagnetic resonance in medicine · 2017Article
- In-vivoAnalytical biochemistry · 2017Review
- Band inversion amplifiesMagnetic resonance in medicine · 2017Article
- A simple approach to evaluate the kinetic rate constant for ATP synthesis in resting human skeletal muscle at 7 T.NMR in biomedicine · 2016Article
- Amplification of the effects of magnetization exchange by (31) P band inversion for measuring adenosine triphosphate synthesis rates in human skeletal muscle.Magnetic resonance in medicine · 2015Article
- (31)P-MRS of healthy human brain: ATP synthesis, metabolite concentrations, pH, and T1 relaxation times.NMR in biomedicine · 2015Article
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4 authors.
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Abstract
purposeTo develop an inversion pulse-based, chemical exchange saturation transfer-like method for detection of (31) P magnetization exchanges among all nuclear magnetic resonance visible metabolites suitable for providing an integrated kinetic analysis of phosphorus exchange reactions in vivo.
methodsThe exchange kinetics by inversion transfer (EKIT) sequence includes application of a frequency-selective inversion pulse arrayed over the range of relevant (31) P frequencies, followed by a constant delay and a hard readout pulse. A series of EKIT spectra, each given by a plot of Z-magnetization for each metabolite of interest versus frequency of the inversion pulse, can be generated from this single data set.
resultsEKIT spectra reflect chemical exchange due to known biochemical reactions, cross-relaxation effects, and relayed magnetization transfers due to both processes. The rate constants derived from EKIT data collected on resting human skeletal muscle were: ATP synthesis via ATP synthase (0.050 ± 0.016 s(-1) ), ATP synthesis via creatine kinase (0.264 ± 0.023 s(-1) ), and cross-relaxation between neighboring spin pairs within ATP (0.164 ± 0.022 s(-1) ).
conclusionEKIT provides a simple, alternative method to detect chemical exchange, cross relaxation, and relayed magnetization transfer effects in human skeletal muscle at 7 T.
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