Evidence map›Paper›PMID 24733023›Full record

ReviewNature reviews. Genetics2014

X chromosome regulation: diverse patterns in development, tissues and disease.

Xinxian Deng, Joel B Berletch, Di K Nguyen, Christine M Disteche

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed
23.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 311 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Single-cell landscape of sex-specific drivers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Review
  10. eLife · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Women With Genetic Epilepsies.Neurology. Genetics · 2025
    Review
  15. Review
  16. Article
  17. Using Organoids to Model Sex Differences in the Human Brain.Biological psychiatry global open science · 2024
    Review
  18. Article
  19. Article
  20. Article

120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xinxian DengDepartment of Pathology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98115, USA.
Joel B BerletchDepartment of Pathology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98115, USA.
Di K NguyenDepartment of Pathology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98115, USA.
Christine M Disteche1] Department of Pathology, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98115, USA. [2] Department of Medicine, School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98115, USA.
University of Washington · US

Funding

Mouse X InactivationR01GM046883 · NIGMS · UNIVERSITY OF WASHINGTON · PI DISTECHE, CHRISTINE M. · 1992 to 2018
$5.9M
Modeling Mammalian GenomesR01GM098039 · NIGMS · UNIVERSITY OF WASHINGTON · PI BLAU, C. ANTHONY · 2011 to 2013
$1.8M
X-linked Genes, Histone Modifications, and BehaviorR01MH083949 · NIMH · WASHINGTON STATE UNIVERSITY · PI XU, JUN · 2010 to 2013
$1.6M
DOSAGE COMPENSATION OF THE ACTIVE X CHROMOSOME IN MAMMALSR01GM079537 · NIGMS · UNIVERSITY OF WASHINGTON · PI DISTECHE, CHRISTINE M. · 2007 to 2010
$1.2M
Mosaic Xlr3 Gene Expression in the Female Embryonic Mouse BrainR21MH099628 · NIMH · SEATTLE CHILDREN'S HOSPITAL · PI HEVNER, ROBERT F · 2013 to 2014
$537k
NIGMS NIH HHS GM046883NIGMS NIH HHS GM098039NIGMS NIH HHS R01 GM046883NIGMS NIH HHS R01 GM079537NIGMS NIH HHS R01 GM098039NIMH NIH HHS MH083949NIMH NIH HHS MH099628NIMH NIH HHS R01 MH083949NIMH NIH HHS R21 MH099628
6 · The paper itself

Abstract

Genes on the mammalian X chromosome are present in one copy in males and two copies in females. The complex mechanisms that regulate the X chromosome lead to evolutionary and physiological variability in gene expression between species, the sexes, individuals, developmental stages, tissues and cell types. In early development, delayed and incomplete X chromosome inactivation (XCI) in some species causes variability in gene expression. Additional diversity stems from escape from XCI and from mosaicism or XCI skewing in females. This causes sex-specific differences that manifest as differential gene expression and associated phenotypes. Furthermore, the complexity and diversity of X dosage regulation affect the severity of diseases caused by X-linked mutations.

Indexed as

Chromosome DisordersChromosomes, Human, XGene Expression RegulationGenetic Diseases, X-LinkedSex CharacteristicsX Chromosome InactivationAnimalsFemaleHumansMaleMosaicism

Identifiers

PMID24733023
PMCPMC4117651
OpenAlexW2076838302

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.