ReviewNature reviews. Endocrinology2014
The pathophysiology of hypertension in patients with obesity.
Review in Nature reviews. Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06509282 (Efficacy of a Personalized Concurrent Exercise Prescription Guide for Controlling Cardiovascular Risk and Enhancing Physical Fitness in Adults From a Cardiovascular Health Program), which is not on this map. Cited by 260 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of a Personalized Concurrent Exercise Prescription Guide for Controlling Cardiovascular Risk and Enhancing Physical Fitness in Adults From a Cardiovascular Health Program: A Pilot Randomized Controlled Clinical Trial.
Who cites it
260 citing papers in PubMed, 7 syntheses or guidelines pooled it, 542 citations in OpenAlex.
- Can resistance training alone or resistance training combined with aerobic training improve arterial stiffness, endothelial function, and other vascular function indicators in adults with hypertension or overweight/obesity-related vascular risk? A systematic review and meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2026Pooled it
- Mapping arterial stiffness metabolic biomarkers: a bibliometric analysis.Frontiers in medicine · 2025Pooled it
- Cardiovascular Benefits of GLP-1 Receptor Agonists in Patients Living with Obesity or Overweight: A Meta-analysis of Randomized Controlled Trials.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024Pooled it
- Association of blood pressure, obesity and physical activity with arterial stiffness in children: a systematic review and meta-analysis.Pediatric research · 2022Pooled it
- Pooled it
- Determinants of systemic hypertension in older adults in Africa: a systematic review.BMC cardiovascular disorders · 2019Pooled it
- Body mass index, abdominal fatness, and hypertension incidence: a dose-response meta-analysis of prospective studies.Journal of human hypertension · 2018Pooled it
- Impact of body mass index on blood pressure and cardiovascular adaptation to isometric exercise training.European journal of applied physiology · 2026Trial
- Trial
- Trial
- Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults.Nutrients · 2020Trial
- Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.Scientific reports · 2019Trial
- Demographic and Lifestyle Predictors of Prehypertension: A Cross-Sectional Study among Apparently Healthy Adults in Kumasi, Ghana.BioMed research international · 2019Trial
- FTO Deficiency Inhibits Vascular Endothelial Cell Apoptosis and Improved Mitophagy in Obesity-Related Hypertension by Enhancing NDRG1 m6A Methylation.Biochemical genetics · 2026Article
- Comparative Analysis of Hypertension Stages Prevalence and Associated Factors in Bangladesh: Evidence From BDHS 2017-18 and 2022.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Influence of body mass index on disease severity and treatment outcomes in primary aldosteronism.Journal of the Endocrine Society · 2026Article
- The Serum Testosterone Level in Male Patients Is Inversely Associated With Hypertension Incidence.Journal of clinical hypertension (Greenwich, Conn.) · 2026Observational
- Association between METS-VF and hypertension in U.S.: a cross-sectional analysis of NHANES data.Scientific reports · 2026Article
- Senolytic treatment with dasatinib and quercetin selectively improves cardiac autonomic balance in obesity.GeroScience · 2026Article
- Renin-to-Aldosterone Ratio Is Associated with Ambulatory Blood Pressure Levels and Control in Treated Hypertensive Patients with Overweight or Obesity.Obesity facts · 2026Article
200 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The combination of obesity and hypertension is associated with high morbidity and mortality because it leads to cardiovascular and kidney disease. Potential mechanisms linking obesity to hypertension include dietary factors, metabolic, endothelial and vascular dysfunction, neuroendocrine imbalances, sodium retention, glomerular hyperfiltration, proteinuria, and maladaptive immune and inflammatory responses. Visceral adipose tissue also becomes resistant to insulin and leptin and is the site of altered secretion of molecules and hormones such as adiponectin, leptin, resistin, TNF and IL-6, which exacerbate obesity-associated cardiovascular disease. Accumulating evidence also suggests that the gut microbiome is important for modulating these mechanisms. Uric acid and altered incretin or dipeptidyl peptidase 4 activity further contribute to the development of hypertension in obesity. The pathophysiology of obesity-related hypertension is especially relevant to premenopausal women with obesity and type 2 diabetes mellitus who are at high risk of developing arterial stiffness and endothelial dysfunction. In this Review we discuss the relationship between obesity and hypertension with special emphasis on potential mechanisms and therapeutic targeting that might be used in a clinical setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.