Evidence map›Paper›PMID 24732949›Full record

ArticlePloS one2014

CXCL10 controls inflammatory pain via opioid peptide-containing macrophages in electroacupuncture.

Ying Wang, Rebekka Gehringer, Shaaban A Mousa, Dagmar Hackel, Alexander Brack, Heike L Rittner

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
20.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ying WangDepartment of Anesthesiology, University Hospital of Würzburg, Würzburg, Germany.
Rebekka GehringerDepartment of Anesthesiology, University Hospital of Würzburg, Würzburg, Germany.
Shaaban A MousaDepartment of Anesthesiology and Critical Care, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.
Dagmar HackelDepartment of Anesthesiology, University Hospital of Würzburg, Würzburg, Germany.
Alexander BrackDepartment of Anesthesiology, University Hospital of Würzburg, Würzburg, Germany.
Heike L RittnerDepartment of Anesthesiology, University Hospital of Würzburg, Würzburg, Germany.
Universitätsklinikum Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acupuncture is widely used for pain treatment in patients with osteoarthritis or low back pain, but molecular mechanisms remain largely enigmatic. In the early phase of inflammation neutrophilic chemokines direct opioid-containing neutrophils in the inflamed tissue and stimulate opioid peptide release and antinociception. In this study the molecular pathway and neuroimmune connections in complete Freund's adjuvant (CFA)-induced hind paw inflammation and electroacupuncture for peripheral pain control were analyzed. Free moving Wistar rats with hind paw inflammation were treated twice with electroacupuncture at GB30 (Huan Tiao--gall bladder meridian) (day 0 and 1) and analyzed for mechanical and thermal nociceptive thresholds. The cytokine profiles as well as the expression of opioid peptides were quantified in the inflamed paw. Electroacupuncture elicited long-term antinociception blocked by local injection of anti-opioid peptide antibodies (beta-endorphin, met-enkephalin, dynorphin A). The treatment altered the cytokine profile towards an anti-inflammatory pattern but augmented interferon (IFN)-gamma and the chemokine CXCL10 (IP-10: interferon gamma-inducible protein) protein and mRNA expression with concomitant increased numbers of opioid peptide-containing CXCR3+ macrophages. In rats with CFA hind paw inflammation without acupuncture repeated injection of CXCL10 triggered opioid-mediated antinociception and increase opioid-containing macrophages. Conversely, neutralization of CXCL10 time-dependently decreased electroacupuncture-induced antinociception and the number of infiltrating opioid peptide-expressing CXCR3+ macrophages. In summary, we describe a novel function of the chemokine CXCL10--as a regulator for an increase of opioid-containing macrophages and antinociceptive mediator in inflammatory pain and as a key chemokine regulated by electroacupuncture.

Indexed as

Pain ThresholdAnimalsAnti-Inflammatory AgentsChemokine CXCL10CytokinesElectroacupunctureEnzyme-Linked Immunosorbent AssayInflammationInterferon-gammaMacrophagesMaleNociceptionOpioid PeptidesPain ManagementPain MeasurementRatsAnti-Inflammatory AgentsChemokine CXCL10Cxcl10 protein, ratCxcr3 protein, ratCytokinesInterferon-gammaOpioid PeptidesReceptors, CXCR3

Identifiers

PMID24732949
PMCPMC3986408
OpenAlexW1992022794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.