Evidence map›Paper›PMID 24732947›Full record

ArticleScientific reports2014

High resolution imaging beyond the acoustic diffraction limit in deep tissue via ultrasound-switchable NIR fluorescence.

Yanbo Pei, Ming-Yuan Wei, Bingbing Cheng, Yuan Liu, Zhiwei Xie, Kytai Nguyen, Baohong Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
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  11. Biomedical optics express · 2020
    Article
  12. Ultrasound-Enhanced Chemiluminescence for Bioimaging.Frontiers in bioengineering and biotechnology · 2020
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanbo Pei1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA [3].
Ming-Yuan Wei1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA [3].
Bingbing Cheng1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA.
Yuan Liu1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA.
Zhiwei Xie1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA [3].
Kytai Nguyen1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA.
Baohong Yuan1] Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA [2] Joint Biomedical Engineering Program, The University of Texas at Arlington and The University of Texas Southwestern Medical Center at Dallas, TX 75390, USA.

Funding

FRET-based Ultrasound-Switchable Fluorescence ImagingR15EB012312 · NIBIB · UNIVERSITY OF TEXAS ARLINGTON · PI YUAN, BAOHONG · 2010 to 2010
$397k
NIBIB NIH HHS 7R15EB012312-02NIBIB NIH HHS R15 EB012312
6 · The paper itself

Abstract

Fluorescence imaging in deep tissue with high spatial resolution is highly desirable because it can provide details about tissue's structural, functional, and molecular information. Unfortunately, current fluorescence imaging techniques are limited either in penetration depth (microscopy) or spatial resolution (diffuse light based imaging) as a result of strong light scattering in deep tissue. To overcome this limitation, we developed an ultrasound-switchable fluorescence (USF) imaging technique whereby ultrasound was used to switch on/off the emission of near infrared (NIR) fluorophores. We synthesized and characterized unique NIR USF contrast agents. The excellent switching properties of these agents, combined with the sensitive USF imaging system developed in this study, enabled us to image fluorescent targets in deep tissue with spatial resolution beyond the acoustic diffraction limit.

Indexed as

AnimalsContrast MediaFluorescenceFluorescent DyesInfrared RaysMusclesNanoparticlesOptical ImagingSwineUltrasonographyContrast MediaFluorescent Dyes

Identifiers

PMID24732947
PMCPMC4003820

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.