ArticleLeukemia2015
Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia.
Article in Leukemia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- The Role of MicroRNAs, CircRNAs, and LncRNAs in Chronic Lymphocytic Leukemia.Current pharmaceutical design · 2025Review
- Role of microRNAs in Chronic Lymphocytic Leukemia.International journal of molecular sciences · 2023Review
- MicroRNA-15a-5p acts as a tumor suppressor in histiocytosis by mediating CXCL10-ERK-LIN28a-let-7 axis.Leukemia · 2022Article
- Small Non-Coding RNAs in Leukemia.Cancers · 2022Review
- Enhanced Expression ofCancers · 2021Article
- Silencing of DLEU2 suppresses pancreatic cancer cell proliferation and invasion by upregulating microRNA-455.Cancer science · 2019Article
- MicroRNAs in Autoimmunity and Hematological Malignancies.International journal of molecular sciences · 2018Review
- Epigenetics and MicroRNAs in Cancer.International journal of molecular sciences · 2018Review
- Discovery and functional implications of a miR-29b-1/miR-29a cluster polymorphism in acute myeloid leukemia.Oncotarget · 2018Article
- Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia: implication for therapy.Leukemia · 2017Article
- Universal attenuators and their interactions with feedback loops in gene regulatory networks.Nucleic acids research · 2017Article
- Chronic lymphocytic leukaemia.Nature reviews. Disease primers · 2017Review
- Evolution of multiple cell clones over a 29-year period of a CLL patient.Nature communications · 2016Article
- Novel mechanisms of regulation of miRNAs in CLL.Trends in cancer · 2016Article
- TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis.Cellular oncology (Dordrecht, Netherlands) · 2015Review
- Role of microRNA in chronic lymphocytic leukemia onset and progression.Journal of hematology & oncology · 2015Review
- MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin.Cancer biology & therapy · 2015Article
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 2 countries.
Funding
Abstract
Deregulation of the miR-15a/16-1 cluster has a key role in the pathogenesis of chronic lymphocytic leukemia (CLL), a clinically heterogeneous disease with indolent and aggressive forms. The miR-15a/16-1 locus is located at 13q14, the most frequently deleted region in CLL. Starting from functional investigations of a rare SNP upstream the miR cluster, we identified a novel allele-specific mechanism that exploits a cryptic activator region to recruit the RNA polymerase III for miR-15a/16-1 transcription. This regulation of the miR-15a/16- locus is independent of the DLEU2 host gene, which is often transcribed monoallellically by RPII. We found that normally one allele of miR-15a/16-1 is transcribed by RNAPII, the other one by RNAPIII. In our subset of CLL patients harboring 13q14 deletions, exclusive RNA polymerase III (RPIII)-driven transcription of the miR-15a/16-1 was the consequence of loss of the RPII-regulated allele and correlated with high expression of the poor prognostic marker ZAP70 (P=0.019). Thus, our findings point to a novel biological process, characterized by double allele-specific transcriptional regulation of the miR-15a/16-1 locus by alternative mechanisms. Differential usage of these mechanisms may distinguish at onset aggressive from indolent forms of CLL. This provides a basis for the clinical heterogeneity of the CLL patients carrying 13q14 deletions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.