ArticleThe Journal of physiology2014
Excitability and responsiveness of rat barrel cortex neurons in the presence and absence of spontaneous synaptic activity in vivo.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Variation and convergence in the morpho-functional properties of the mammalian neocortex.Frontiers in systems neuroscience · 2024Review
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- Between life and death: the brain twilight zones.Frontiers in neuroscience · 2023Review
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- GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation.Nature neuroscience · 2021Article
- Review: How do spontaneous and sensory-evoked activities interact?Neurophotonics · 2017Review
- Mesoscale Architecture Shapes Initiation and Richness of Spontaneous Network Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Integrative properties and transfer function of cortical neurons initiating absence seizures in a rat genetic model.The Journal of physiology · 2016Article
- Heterogeneous firing rate response of mouse layer V pyramidal neurons in the fluctuation-driven regime.The Journal of physiology · 2016Article
- Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo.Journal of visualized experiments : JoVE · 2016Article
- Mechanisms of Self-Sustained Oscillatory States in Hierarchical Modular Networks with Mixtures of Electrophysiological Cell Types.Frontiers in computational neuroscience · 2016Article
- Post-stroke fatigue: a deficit in corticomotor excitability?Brain : a journal of neurology · 2015Article
- How neuronal computations depend on network state: another piece in the puzzle.The Journal of physiology · 2014Article
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Abstract
The amplitude and temporal dynamics of spontaneous synaptic activity in the cerebral cortex vary as a function of brain states. To directly assess the impact of different ongoing synaptic activities on neocortical function, we performed in vivo intracellular recordings from barrel cortex neurons in rats under two pharmacological conditions generating either oscillatory or tonic synaptic drive. Cortical neurons membrane excitability and firing responses were compared, in the same neurons, before and after complete suppression of background synaptic drive following systemic injection of a high dose of anaesthetic. Compared to the oscillatory state, the tonic pattern resulted in a more depolarized and less fluctuating membrane potential (Vm), a lower input resistance (Rm) and steeper relations of firing frequency versus injected current (F-I). Whatever their temporal dynamics, suppression of background synaptic activities increased mean Vm, without affecting Rm, and induced a rightward shift of F-I curves. Both types of synaptic drive generated a high variability in current-induced firing rate and patterns in cortical neurons, which was much reduced after removal of spontaneous activity. These findings suggest that oscillatory and tonic synaptic patterns differentially facilitate the input-output function of cortical neurons but result in a similar moment-to-moment variability in spike responses to incoming depolarizing inputs.
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