ArticleThe Journal of investigative dermatology2014
Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis.
Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
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- Microalgae and Human Disorders: Mechanistic Insights and Therapeutic Potential.Current topics in medicinal chemistry · 2025Review
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- Potential UV-Protective Effect of Freestanding Biodegradable Nanosheet-Based Sunscreen Preparations inPharmaceutics · 2022Article
- Beneficial Effects of Spirulina Consumption on Brain Health.Nutrients · 2022Review
- Evaluation of Acute Reactions on Mouse Skin Irradiated with 222 and 235 nm UV-C.Photochemistry and photobiology · 2021Article
- Effects of fluctuating temperature in open raceway ponds on the biomass accumulation and harvest efficiency of Spirulina in large-scale cultivation.Environmental science and pollution research international · 2021Article
- Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models.Molecular vision · 2021Review
- Topical Application ofMolecules (Basel, Switzerland) · 2020Article
- Inhibitors of DNA Glycosylases as Prospective Drugs.International journal of molecular sciences · 2020Review
- Crude protein from spirulina increases the viability of CCD‑986sk cells via the EGFR/MAPK signaling pathway.International journal of molecular medicine · 2019Article
- Dose Effects of Orally AdministeredFrontiers in cellular and infection microbiology · 2019Article
- Arthrospira Platensis - Potential in Dermatology and Beyond.Open access Macedonian journal of medical sciences · 2018Review
- Neuroprotective Activities of Spirulina platensis in the 6-OHDA Model of Parkinson's Disease Are Related to Its Anti-Inflammatory Effects.Neurochemical research · 2017Article
- Systematic Overview of Bacopa monnieri (L.) Wettst. Dominant Poly-Herbal Formulas in Children and Adolescents.Medicines (Basel, Switzerland) · 2017Review
- Edible Cyanobacterial GenusFrontiers in microbiology · 2017Review
- Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice.Advances in pharmacological sciences · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species produced in response to UVR are important in skin tumor development. We have previously reported that deficiency of the Ogg1 gene, encoding the repair enzyme for 8-oxo-7,8-dihydroguanine (8-oxoG), increases skin tumor incidence in mice upon repetitive UVB exposure and modulation of UVB-induced inflammatory response. Spirulina platensis is used as a human food supplement because it contains abundant nutritional and antioxidant components. Therefore, we investigated the inhibitory effects of S. platensis on UVB-induced skin tumor development in Ogg1 knockout-(KO) mice and the wild-type (WT) counterpart. Dietary S. platensis suppressed tumor induction and development in both genotypes compared with our previous data without S. platensis. Induction of erythema and ear swelling, one of the hallmarks of UVB-induced inflammatory responses, was suppressed in the skin of Ogg1-KO mice and albino hairless mice fed with dietary S. platensis. Compared with untreated mice, S. platensis-administered mice showed significantly reduced 8-oxoG formation in the skin after UVB exposure. Moreover, we found that S. platensis effectively downregulated the signal proteins p38 mitogen-activated protein kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and extracellular signal-regulated kinase after UVB exposure especially in Ogg1-KO mice. Our results suggest that S. platensis exerts antitumor effects against UVB irradiation in the skin through its anti-inflammatory and antioxidant effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.