Evidence map›Paper›PMID 24732369›Full record

ArticleHeart rhythm2014

Oral contraceptive use and the risk of cardiac events in patients with long QT syndrome.

Abeer Abu-Zeitone, Derick R Peterson, Bronislava Polonsky, Scott McNitt, Arthur J Moss

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Management of Patients with Long QT Syndrome.Korean circulation journal · 2016
    Review
  5. Deranged sodium to sudden death.The Journal of physiology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Abeer Abu-ZeitoneHeart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York. Electronic address: abeer_abuzeitone@urmc.rochester.edu.
Derick R PetersonDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York.
Bronislava PolonskyHeart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York.
Scott McNittHeart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York.
Arthur J MossHeart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York.
University of Rochester Medical Center · US

Funding

LONG QT SYNDROME--POPULATION, GENETIC, &CARDIAC STUDIESR01HL033843 · NHLBI · UNIVERSITY OF ROCHESTER · PI MOSS, ARTHUR J. · 1985 to 2011
$5.9M
The University of Rochester's Clinical and Translational Science InstituteTL1RR024135 · NCRR · UNIVERSITY OF ROCHESTER · PI PEARSON, THOMAS ARTHUR · 2006 to 2011
$3.7M
LONG QT SYNDROME--GENETIC STUDIESR01HL051618 · NHLBI · UNIVERSITY OF ROCHESTER · PI MOSS, ARTHUR J. · 1993 to 2002
$1.2M
The University of Rochester Clinical and Translational Science InstituteTL1TR000096 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$930k
NCATS NIH HHS TL1 TR000096NCRR NIH HHS TL1 RR024135NCRR NIH HHS TL1RR024135NHLBI NIH HHS HL-33843NHLBI NIH HHS HL-51618NHLBI NIH HHS R01 HL033843NHLBI NIH HHS R01 HL051618
6 · The paper itself

Abstract

backgroundIn prior clinical studies of patients with long QT syndrome (LQTS), pregnancy was associated with fewer cardiac events (CEs) compared to before or after pregnancy. In recent animal studies involving rabbits with LQTS mutations, progesterone had favorable effects on CEs compared to estrogen. The effect of oral contraceptive therapy with its high progesterone/estrogen ratio on the risk of CEs in patients with LQTS has not been examined.

objectiveTo study the effect of oral contraceptive use on the risk of CEs in patients with LQTS.

methodsWe studied 174 patients from the Rochester-based LQTS Registry who responded to a questionnaire about their oral contraceptive use. We used time-dependent Cox regression to estimate the hazard ratio for recurrent CEs when patients were using vs not using oral contraceptives during nonpregnancy periods. For this recurrent events analysis, the Prentice-Williams-Peterson model was used and the time origin was defined as the onset of menarche. We adjusted for the baseline corrected QT interval, history of CEs before menarche, age at menarche onset, number of births, time-dependent β-blocker therapy, and LQTS genotype.

resultsNo differences in the risk of CEs for the times patients with LQTS were using vs not using oral contraceptives was found in the general population with LQTS (hazard ratio 1.01; P = .95) or in analyses of LQTS subsets (P > .2).

conclusionOral contraceptive therapy use did not affect LQTS-related CEs in the study population. Oral contraceptives did not show beneficial or harmful effects in this patient group.

Indexed as

AdultContraceptives, OralFemaleFollow-Up StudiesHeart ArrestHumansIncidenceLong QT SyndromeMiddle AgedPregnancyRegistriesRisk FactorsContraceptives, OralCardiac eventsEstrogenI(Kr) channelsI(Ks) channelsLong QT syndromeOral contraceptive therapyPregnancyProgesteroneSex hormones

Identifiers

PMID24732369
PMCPMC4065807
OpenAlexW2088886631

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.