SynthesisPloS one2014
Relationship between interleukin-10 -1082A/G polymorphism and risk of ischemic stroke: a meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Association between the IL-10-1082G/A, IL-10-819T/C and IL-10-592A/C polymorphisms and Brucellosis susceptibility: a meta-analysis.Epidemiology and infection · 2019Pooled it
- Pooled it
- Associations of thyroid function, inflammatory cytokines, and ceramides with 30-day functional outcome after acute ischemic stroke.BMC neurology · 2026Article
- The Prognostic Determinant of Interleukin-10 in Patients with Acute Ischemic Stroke: An Analysis from the Perspective of Disease Management.Disease markers · 2021Article
- Article
- Identification of Functional Genetic Polymorphisms at IL-10 Promoter Region and their Association with Risk of Ischemic Stroke in Chinese Han Population.The journal of nutrition, health & aging · 2018Article
- Role of Interleukin-10 in Acute Brain Injuries.Frontiers in neurology · 2017Review
- Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis.Bioscience reports · 2016Article
- Genomics of Atrial Fibrillation.Current cardiology reports · 2016Review
- Interaction Between CYP4F2 rs2108622 and CPY4A11 rs9333025 Variants Is Significantly Correlated with Susceptibility to Ischemic Stroke and 20-Hydroxyeicosatetraenoic Acid Level.Genetic testing and molecular biomarkers · 2016Article
- Association of CYP2J2 gene polymorphisms with ischemic stroke.International journal of clinical and experimental medicine · 2015Article
- Association between alpha-1 antichymotrypsin gene A/T polymorphism and primary intracerebral hemorrhage: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Tumour necrosis factor alpha, ınterleukin 10 and ınterleukin 6 gene polymorphisms of ıschemic stroke patients ın south Marmara region of Turkey.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze the association between -1082A/G polymorphism in interleukin-10 (IL-10) gene and ischemic stroke (IS) risk by meta-analysis.
methodsWe carried out a systematic electronic search in PubMed, BIOSIS Previews, Science Direct, Chinese National Knowledge Infrastructure, Chinese Biomedical Database, Weipu database and WANGFANG Database. Pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated to assess the strength of the association.
results7 studies were included. There was no significant association between IL-10 -1082A/G polymorphism and IS risk under all genetic models in overall estimates (A vs. G: OR = 1.23,95%CI = 0.85-1.79;AA vs. GG: OR = 1.01,95%CI = 0.47-2.19; AG vs. GG: OR = 0.76, 95%CI = 0.38-1.55; AA+AG vs. GG: OR = 0.89,95%CI = 0.46-1.73; AA vs. AG+GG: OR = 1.39, 95%CI = 0.91-2.13). Similarly, no associations were found in subgroup analysis based on ethnicity and source of controls. However, removing the study deviating from Hardy-Weinberg equilibrium (HWE) produced statistically significant associations for overall estimates under recessive model(AA VS. AG+GG OR 1.58, 95% CI 1.04-2.42) and among Asians in all genetic models (A VS.G OR 1.64, 95% CI 1.07-2.53; AA vs. GG OR1.91, 95% CI 1.31-2.80; AG vs. GG OR1.44, 95% CI 1.09-1.91; AA+AG vs. GG OR 1.54, 95% CI 1.18-2.01;AA VS. AG+GG OR 1.79, 95% CI 1.07-3.00). Even after Bonferroni correction, the associations were observed still significantly in Asians under the two models (AA vs. GG OR1.91, 95% CI 1.31-2.80, P = 0.0008; AA+AG vs. GG OR 1.54, 95% CI 1.18-2.01, P = 0.001).
conclusionThis meta-analysis indicates that IL10 -1082 A/G polymorphism is associated with IS susceptibility in Asians and the -1082 A allele may increase risk of IS in Asians. Considering the sample size is small and between-study heterogeneity is remarkable, more studies with subtle design are warranted in future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.