ArticlePloS one2014
Thrombocytopenia is associated with acute respiratory distress syndrome mortality: an international study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Association between thrombocytopenia and development of acute respiratory distress syndrome.Respiratory research · 2026Pooled it
- Histopathological findings and clinicopathologic correlation in COVID-19: a systematic review.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Pooled it
- Ulinastatin treatment for acute respiratory distress syndrome in China: a meta-analysis of randomized controlled trials.BMC pulmonary medicine · 2019Pooled it
- Low platelet count as risk factor for infections in patients with primary immune thrombocytopenia: a retrospective evaluation.Annals of hematology · 2018Trial
- Neutrophil-to-Lymphocyte Ratio, Systemic Immune-Inflammation Index, and HALP Score as Predictors of Mortality in Acute Respiratory Distress Syndrome.Journal of clinical medicine · 2026Article
- What I talk about when I talk about patient self-inflicted lung injury: an ultrastructural perspective.Intensive care medicine experimental · 2026Article
- Clinical models for predicting 30-day mortality in ARDS: A focus on ventilatory ratio-defined subgroups.Journal of intensive medicine · 2026Article
- The Unexpected Protective Role of Thrombosis in Lung Injury via Endothelial Alox15.Circulation research · 2026Article
- Sepsis-induced immunothrombosis: from cellular crosstalk to multiple organ dysfunction.Frontiers in immunology · 2026Review
- A Predictive Model for Moderate or Severe Neonatal Acute Respiratory Distress Syndrome in Extremely Preterm Infants with Premature Rupture of Membranes: Development and Internal Validation.Journal of inflammation research · 2026Article
- Non-linear relationship between platelet count and 30-day in-hospital mortality in ICU patients with acute myocardial infarction: a multicenter retrospective cohort study.Scientific reports · 2025Article
- The Lung Is Not a Primary Site of Platelet Biogenesis.Physiological research · 2025Article
- Platelet count has a nonlinear association with 30-day in-hospital mortality in ICU end-stage kidney disease patients: a multicenter retrospective cohort study.Scientific reports · 2024Article
- Platelet count as a prognostic marker for acute respiratory distress syndrome.BMC pulmonary medicine · 2024Article
- Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- A Murine Model of Vesicant-Induced Acute Lung Injury.The Journal of pharmacology and experimental therapeutics · 2024Article
- Association between platelet count and 30-day in-hospital mortality among intensive care unit patients with sepsis: a multicenter retrospective cohort study.Frontiers in medicine · 2024Article
- Nonlinear relationship between platelet count and 30-day in-hospital mortality in intensive care unit stroke patients: a multicenter retrospective cohort study.Frontiers in neurology · 2024Article
- Risk of Acute Respiratory Distress Syndrome in Community-Acquired Pneumonia Patients: Use of an Artificial Neural Network Model.Emergency medicine international · 2023Article
- Prognostic value of neutrophils to lymphocytes and platelets ratio for 28-day mortality in patients with acute respiratory distress syndrome: a retrospective study.BMC pulmonary medicine · 2022Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundEarly detection of the Acute Respiratory Distress Syndrome (ARDS) has the potential to improve the prognosis of critically ill patients admitted to the intensive care unit (ICU). However, no reliable biomarkers are currently available for accurate early detection of ARDS in patients with predisposing conditions.
objectivesThis study examined risk factors and biomarkers for ARDS development and mortality in two prospective cohort studies.
methodsWe examined clinical risk factors for ARDS in a cohort of 178 patients in Beijing, China who were admitted to the ICU and were at high risk for ARDS. Identified biomarkers were then replicated in a second cohort of1,878 patients in Boston, USA.
resultsOf 178 patients recruited from participating hospitals in Beijing, 75 developed ARDS. After multivariate adjustment, sepsis (odds ratio [OR]:5.58, 95% CI: 1.70-18.3), pulmonary injury (OR: 3.22; 95% CI: 1.60-6.47), and thrombocytopenia, defined as platelet count <80×10(3)/µL, (OR: 2.67; 95% CI: 1.27-5.62)were significantly associated with increased risk of developing ARDS. Thrombocytopenia was also associated with increased mortality in patients who developed ARDS (adjusted hazard ratio [AHR]: 1.38, 95% CI: 1.07-1.57) but not in those who did not develop ARDS(AHR: 1.25, 95% CI: 0.96-1.62). The presence of both thrombocytopenia and ARDS substantially increased 60-day mortality. Sensitivity analyses showed that a platelet count of <100×10(3)/µL in combination with ARDS provide the highest prognostic value for mortality. These associations were replicated in the cohort of US patients.
conclusionsThis study of ICU patients in both China and US showed that thrombocytopenia is associated with an increased risk of ARDS and platelet count in combination with ARDS had a high predictive value for patient mortality.
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Registered trials
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