Evidence map›Paper›PMID 24732203›Full record

ReviewToxins2014

Recent developments in antibody-based assays for the detection of bacterial toxins.

Kui Zhu, Richard Dietrich, Andrea Didier, Dominik Doyscher, Erwin Märtlbauer

Abstract readReview
In one paragraph

Review in Toxins, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Quantum Dots as Biosensors in the Determination of Biochemical Parameters in Xenobiotic Exposure and Toxins.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021
    Review
  7. Review
  8. Modern Tools for Rapid Diagnostics of Antimicrobial Resistance.Frontiers in cellular and infection microbiology · 2020
    Review
  9. Utilization of Small RNA Genes to DistinguishThe American journal of tropical medicine and hygiene · 2019
    Article
  10. Article
  11. Theranostics Aspects of Various Nanoparticles in Veterinary Medicine.International journal of molecular sciences · 2018
    Review
  12. Review
  13. The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis.Journal of controlled release : official journal of the Controlled Release Society · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kui ZhuInstitute of Food Science, Department of Veterinary Sciences, Ludwig-Maximilians-University Munich, Oberschleißheim 85764, Germany. zhukcau@gmail.com.
Richard DietrichInstitute of Food Science, Department of Veterinary Sciences, Ludwig-Maximilians-University Munich, Oberschleißheim 85764, Germany. r.dietrich@mh.vetmed.uni-muenchen.de.
Andrea DidierInstitute of Food Science, Department of Veterinary Sciences, Ludwig-Maximilians-University Munich, Oberschleißheim 85764, Germany. a.didier@mh.vetmed.uni-muenchen.de.
Dominik DoyscherInstitute of Food Science, Department of Veterinary Sciences, Ludwig-Maximilians-University Munich, Oberschleißheim 85764, Germany. dominik.doyscher@mh.vetmed.uni-muenchen.de.
Erwin MärtlbauerInstitute of Food Science, Department of Veterinary Sciences, Ludwig-Maximilians-University Munich, Oberschleißheim 85764, Germany. e.maertlbauer@mh.vetmed.uni-muenchen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the urgent demand for rapid and accurate determination of bacterial toxins and the recent promising developments in nanotechnology and microfluidics, this review summarizes new achievements of the past five years. Firstly, bacterial toxins will be categorized according to their antibody binding properties into low and high molecular weight compounds. Secondly, the types of antibodies and new techniques for producing antibodies are discussed, including poly- and mono-clonal antibodies, single-chain variable fragments (scFv), as well as heavy-chain and recombinant antibodies. Thirdly, the use of different nanomaterials, such as gold nanoparticles (AuNPs), magnetic nanoparticles (MNPs), quantum dots (QDs) and carbon nanomaterials (graphene and carbon nanotube), for labeling antibodies and toxins or for readout techniques will be summarized. Fourthly, microscale analysis or minimized devices, for example microfluidics or lab-on-a-chip (LOC), which have attracted increasing attention in combination with immunoassays for the robust detection or point-of-care testing (POCT), will be reviewed. Finally, some new materials and analytical strategies, which might be promising for analyzing toxins in the near future, will be shortly introduced.

Indexed as

AnimalsAntibodiesBacterial ToxinsBinding Sites, AntibodyHumansImmunoassayMicrofluidic Analytical TechniquesNanostructuresNanotechnologyAntibodiesBacterial Toxins

Identifiers

PMID24732203
PMCPMC4014736

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.