ArticlePloS one2014
Apocrine secretion in Drosophila salivary glands: subcellular origin, dynamics, and identification of secretory proteins.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Independent roles of autophagy and apoptosis in post-apocrine-secretion cell death of salivary glands during Drosophila metamorphosis.Scientific reports · 2026Article
- The Drosophila larval salivary gland, a simple and elegant model system to understand secretory organ development and function.Current opinion in insect science · 2026Review
- Developmentally-regulated post-apocrine cell death ofFrontiers in cell and developmental biology · 2026Article
- Article
- Population parameters of Drosophila larval cooperative foraging.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Gross morphology and adhesion-associated physical properties of Drosophila larval salivary gland glue secretion.Scientific reports · 2024Article
- Roles of herbivorous insects salivary proteins.Heliyon · 2024Review
- A salivary GMC oxidoreductase of Manduca sexta re-arranges the green leaf volatile profile of its host plant.Nature communications · 2023Article
- Article
- Fine structural aspects on the web glue production in the golden orb-web spiderAnimal cells and systems · 2023Article
- Genome sequence and silkomics of the spindle ermine moth, Yponomeuta cagnagella, representing the early diverging lineage of the ditrysian Lepidoptera.Communications biology · 2022Article
- Epiblast fragmentation by shedding-a novel mechanism to eliminate cells in post-implantation mouse embryos.Cell death and differentiation · 2022Article
- Release of DNA fromAnimals : an open access journal from MDPI · 2022Article
- Spectacular alterations in the female reproductive system during the ovarian cycle and adaptations for matrotrophy in chernetid pseudoscorpions (Pseudoscorpiones: Chernetidae).Scientific reports · 2022Article
- Morphological and histological description of the midgut caeca in true crabs (Malacostraca: Decapoda: Brachyura): origin, development and potential role.BMC zoology · 2022Article
- Apocrine secretion in the salivary glands ofFrontiers in cell and developmental biology · 2022Article
- Using the multi-omics approach to reveal the silk composition inFrontiers in molecular biosciences · 2022Article
- The Role of Filippi's Glands in the Silk Moths Cocoon Construction.International journal of molecular sciences · 2021Article
- An apocrine mechanism delivers a fully immunocompetent exocrine secretion.Scientific reports · 2021Article
- SLIDE-Novel Approach to Apocrine Sweat Sampling for Lipid Profiling in Healthy Individuals.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to the well defined mechanism of merocrine exocytosis, the mechanism of apocrine secretion, which was first described over 180 years ago, remains relatively uncharacterized. We identified apocrine secretory activity in the late prepupal salivary glands of Drosophila melanogaster just prior to the execution of programmed cell death (PCD). The excellent genetic tools available in Drosophila provide an opportunity to dissect for the first time the molecular and mechanistic aspects of this process. A prerequisite for such an analysis is to have pivotal immunohistochemical, ultrastructural, biochemical and proteomic data that fully characterize the process. Here we present data showing that the Drosophila salivary glands release all kinds of cellular proteins by an apocrine mechanism including cytoskeletal, cytosolic, mitochondrial, nuclear and nucleolar components. Surprisingly, the apocrine release of these proteins displays a temporal pattern with the sequential release of some proteins (e.g. transcription factor BR-C, tumor suppressor p127, cytoskeletal β-tubulin, non-muscle myosin) earlier than others (e.g. filamentous actin, nuclear lamin, mitochondrial pyruvate dehydrogenase). Although the apocrine release of proteins takes place just prior to the execution of an apoptotic program, the nuclear DNA is never released. Western blotting indicates that the secreted proteins remain undegraded in the lumen. Following apocrine secretion, the salivary gland cells remain quite vital, as they retain highly active transcriptional and protein synthetic activity.
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