Evidence map›Paper›PMID 24731978›Full record

ReviewGerontology2014

Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options - a mini-review.

Sumbul Ali, Jose M Garcia

3 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gerontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 221 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 9 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03530774 nacompletednot on this mapstarted 2017, after this paper: background citation

Egg Protein Supplementation for Maintaining Muscle Mass and Function in Older Adults

TypeinterventionalSponsorThe University of Texas at San AntonioRan2017 to 2018Enrolled54ConditionsSarcopenia, AgingArmspowdered egg white protein supplement, maltodextrin supplement
NCT03809104 nacompletednot on this mapstarted 2019, after this paper: background citation

Virtual Reality-based Rehabilitation in the Treatment and Prevention of Sarcopenia of Older Residents in Caring Facilities - a Pilot Study in Rural Southern Taiwan

TypeinterventionalSponsorCishan Hospital, Ministry of Health and WelfareRan2019 to 2019Enrolled43ConditionsSarcopeniaArmsVirtual reality-based rehabilitation programs
NCT07513025 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Clinical Effectiveness of Progressive Resistance Training With Elastic Band in Postponing and Preventing Sarcopenia Among Older Adults in Rural Long-Term Care Facilities

TypeinterventionalSponsorCishan Hospital, Ministry of Health and WelfareRan2026 to 2026Enrolled60ConditionsSarcopenia, Long Term Care FacilityArmselastic band
3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 9 syntheses or guidelines pooled it, 449 citations in OpenAlex.

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  9. Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2019
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161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sumbul AliDivision of Diabetes, Endocrinology and Metabolism, MCL, Center for Translational Research in Inflammatory Diseases, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Tex., USA.
Jose M Garcia
Karger Publishers (Switzerland) · CH

Funding

CELL &MOLECULAR BIOLOGY OF AGINGT32AG000183 · NIA · BAYLOR COLLEGE OF MEDICINE · PI DONEHOWER, LAWRENCE A. · 1989 to 2015
$3.7M
The role of ghrelin and the ghrelin receptor GHSR1a in sarcopenia of agingR03AG040583 · NIA · BAYLOR COLLEGE OF MEDICINE · PI GARCIA, JOSE M. · 2011 to 2012
$157k
Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related caI01BX000507 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI GARCIA, JOSE M. · 2009 to 2013
–
The Role of Ghrelin in Cancer CachexiaI01CX000174 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI GARCIA, JOSE M. · 2009 to 2014
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BLRD VA I01 BX000507BLRD VA I01 BX002807CSRD VA I01 CX000174NIA NIH HHS AG040583NIA NIH HHS R03 AG040583NIA NIH HHS T32 AG000183NIA NIH HHS T32AG000183
6 · The paper itself

Abstract

By the year 2050, individuals over the age of 65 years will comprise 20% of the US population. Loss of muscle mass and strength is common in this age group and it is associated with increased dependence, frailty and mortality. Sarcopenia, defined as the loss of muscle mass and function associated with aging, and cachexia, defined as weight loss due to an underlying illness, are muscle wasting disorders of particular relevance in the aging population, but they go largely unrecognized. In this review we highlight the common pathophysiological mechanisms underlying muscle loss in sarcopenia and cachexia, the factors unique to each condition and means of diagnosing and differentiating them clinically. Therapeutic options including exercise, nutritional therapy, androgens and growth hormone as well as their practical limitations are discussed. We also shed light on newer agents being developed as potential therapeutic options for wasting diseases.

Indexed as

CachexiaSarcopeniaAgedAgingAndrogensAppetite StimulantsDietary ProteinsExercise TherapyGhrelinHuman Growth HormoneHumansMuscle ProteinsMuscle, SkeletalReceptors, AndrogenAndrogensAppetite StimulantsAR protein, humanDietary ProteinsGhrelinHuman Growth HormoneMuscle ProteinsReceptors, Androgen

Identifiers

PMID24731978
PMCPMC4112511
OpenAlexW2124477946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.