ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2014
Association of apolipoprotein E-e4 and dementia declines with age.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Interplay Between 3D Chromatin Architecture and Gene Regulation at theInternational journal of molecular sciences · 2025Article
- Impact of age and apolipoprotein E ε4 status on regional white matter hyperintensity volume and cognition in healthy aging.Journal of the International Neuropsychological Society : JINS · 2024Article
- Distinct age-related associations for body mass index and cognition in cognitively healthy very old veterans.International psychogeriatrics · 2019Article
- Associations of hemoglobin A1c with cognition reduced for long diabetes duration.Alzheimer's & dementia (New York, N. Y.) · 2019Article
- Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment.Molecular psychiatry · 2017Article
- Dementia Risk and Protective Factors Differ in the Context of Memory Trajectory Groups.Journal of Alzheimer's disease : JAD · 2016Article
- Aging is a weak but relentless determinant of dementia severity.Oncotarget · 2016Article
- Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study.BMC psychiatry · 2014Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
objectiveTo study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample).
methodsIn both case-control studies, participants were cognitively intact or diagnosed with dementia. The N-sample (N = 112) was at least age 90 years; the GE-sample (N = 98) was at least age 65 years.
resultsDementia and APOE-e4 were not significantly associated in the N-sample, but were in the GE-sample. There was a significant interaction of age with APOE-e4 in the N-sample, but not in the GE-sample. Descriptively dividing the N-sample at the median (age 93 years) showed a group interaction: APOE-e4 was more associated with dementia in the younger N-sample than in the older N-sample, where six of seven APOE-e4 carriers were cognitively intact.
conclusionsThe results support the reduction in association of APOE-e4 with dementia in extreme old age, consistent with a survivor effect model for successful cognitive aging.
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Registered trials
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