ArticleBMC biology2014
Genomic composition and evolution of Aedes aegypti chromosomes revealed by the analysis of physically mapped supercontigs.
Article in BMC biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 65 citations in OpenAlex.
- Chromosomal Inversions and Their Potential Impact on the Evolution of Arboviral Vector Aedes aegypti.Genome biology and evolution · 2025Article
- The chromosome-scale genome assembly for the West Nile vector Culex quinquefasciatus uncovers patterns of genome evolution in mosquitoes.BMC biology · 2024Article
- A DBHS family member regulates male determination in the filariasis vector Armigeres subalbatus.Nature communications · 2023Article
- Review
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- Genetic stability of Aedes aegypti populations following invasion by wMel Wolbachia.BMC genomics · 2021Article
- Article
- A selectable, plasmid-based system to generate CRISPR/Cas9 gene edited and knock-in mosquito cell lines.Scientific reports · 2021Article
- Irradiation induced inversions suppress recombination between the M locus and morphological markers in Aedes aegypti.BMC genetics · 2020Article
- Establishment and characterization of a cell line from Ghanaian Aedes aegypti (Diptera: Culicidae) focusing on Aedes-borne flavivirus susceptibility.In vitro cellular & developmental biology. Animal · 2020Article
- A single unidirectional piRNA cluster similar to theRNA (New York, N.Y.) · 2020Article
- Chromatin Structure and Function in Mosquitoes.Frontiers in genetics · 2020Review
- The Nix locus on the male-specific homologue of chromosome 1 in Aedes albopictus is a strong candidate for a male-determining factor.Parasites & vectors · 2018Article
- Article
- Extensive Genetic Differentiation between Homomorphic Sex Chromosomes in the Mosquito Vector, Aedes aegypti.Genome biology and evolution · 2017Article
- Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae.Malaria journal · 2017Article
- Exon-Enriched Libraries Reveal Large Genic Differences BetweenG3 (Bethesda, Md.) · 2017Article
- Identification and initial characterization of matrix metalloproteinases in the yellow fever mosquito, Aedes aegypti.Insect molecular biology · 2017Article
- Proteomics informed by transcriptomics for characterising active transposable elements and genome annotation in Aedes aegypti.BMC genomics · 2017Article
- Proteomics technique opens new frontiers in mobilome research.Mobile genetic elements · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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Abstract
backgroundAn initial comparative genomic study of the malaria vector Anopheles gambiae and the yellow fever mosquito Aedes aegypti revealed striking differences in the genome assembly size and in the abundance of transposable elements between the two species. However, the chromosome arms homology between An. gambiae and Ae. aegypti, as well as the distribution of genes and repetitive elements in chromosomes of Ae. aegypti, remained largely unexplored because of the lack of a detailed physical genome map for the yellow fever mosquito.
resultsUsing a molecular landmark-guided fluorescent in situ hybridization approach, we mapped 624 Mb of the Ae. aegypti genome to mitotic chromosomes. We used this map to analyze the distribution of genes, tandem repeats and transposable elements along the chromosomes and to explore the patterns of chromosome homology and rearrangements between Ae. aegypti and An. gambiae. The study demonstrated that the q arm of the sex-determining chromosome 1 had the lowest gene content and the highest density of minisatellites. A comparative genomic analysis with An. gambiae determined that the previously proposed whole-arm synteny is not fully preserved; a number of pericentric inversions have occurred between the two species. The sex-determining chromosome 1 had a higher rate of genome rearrangements than observed in autosomes 2 and 3 of Ae. aegypti.
conclusionsThe study developed a physical map of 45% of the Ae. aegypti genome and provided new insights into genomic composition and evolution of Ae. aegypti chromosomes. Our data suggest that minisatellites rather than transposable elements played a major role in rapid evolution of chromosome 1 in the Aedes lineage. The research tools and information generated by this study contribute to a more complete understanding of the genome organization and evolution in mosquitoes.
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