ArticleAnnals of epidemiology2014
Oxidative balance score and risk for incident prostate cancer in a prospective U.S. cohort study.
Article in Annals of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies.BMC cancer · 2023Pooled it
- A Review ofNutrients · 2019Pooled it
- Observational
- Relationship between oxidative balance score and health-related quality of life in Korean adults.PloS one · 2025Article
- Relationship between oxidative balance score and prostate cancer: a cross-sectional study of NHANES, 1999-2010.BMJ open · 2024Article
- Association between oxidative balance score and sarcopenia in older adults.Scientific reports · 2024Article
- Oxidative Balance Score and New-Onset Type 2 Diabetes Mellitus in Korean Adults without Non-Alcoholic Fatty Liver Disease: Korean Genome and Epidemiology Study-Health Examinees (KoGES-HEXA) Cohort.Antioxidants (Basel, Switzerland) · 2024Article
- Association of oxidative balance score with chronic kidney disease: NHANES 1999-2018.Frontiers in endocrinology · 2024Article
- Article
- Association between oxidative balance score in adults with and without chronic kidney disease: 2011-2028 NHANES.Frontiers in nutrition · 2024Article
- Association between the oxidative balance score and low muscle mass in middle-aged US adults.Frontiers in nutrition · 2024Article
- The Association between Oxidative Balance Score and Urinary Levels of 8-Hydroxydeoxyguanosine among Japanese Adults.Nutrients · 2023Article
- Inverse Association between Oxidative Balance Score and Incident Type 2 Diabetes Mellitus.Nutrients · 2023Article
- Oxidative balance score and dietary phytochemical index can reduce the risk of colorectal cancer in Iranian population.BMC gastroenterology · 2023Article
- Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case-control study.Scientific reports · 2023Article
- Association between the Oxidative Balance Score and Incident Chronic Kidney Disease in Adults.Antioxidants (Basel, Switzerland) · 2023Article
- Dietary Antioxidant Capacity Indices are Negatively Correlated to LDL-Oxidation in Adults.International journal of clinical practice · 2023Article
- Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population.Frontiers in nutrition · 2023Article
- Association between oxidative stress exposure and colorectal cancer risk in 98,395 participants: results from a prospective study.Frontiers in nutrition · 2023Article
- Oxidative balance score reflects vascular endothelial function of Chinese community dwellers.Frontiers in physiology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeOxidative stress is defined as an imbalance between pro-oxidants and antioxidants. Previous research found that a single comprehensive oxidative balance score (OBS) that includes individual pro- and anti-oxidant exposures may be associated with various conditions (including prostate cancer) in the absence of associations with the individual factors. We investigated an OBS-incident prostate cancer association among 43,325 men in the Cancer Prevention Study II Nutrition Cohort.
methodsFrom 1999-2007, 3386 incident cases were identified. Twenty different components, used in two ways (unweighted or weighted based on literature reviews), were incorporated into the OBS, and the resulting scores were then expressed as three types of variables (continuous, quartiles, or six equal intervals). Multivariable-adjusted rate ratios were calculated using Cox proportional hazards models.
resultsWe hypothesized that the OBS would be inversely associated with prostate cancer risk; however, the rate ratios (95% confidence intervals) comparing the highest with the lowest OBS categories ranged from 1.17 (1.04-1.32) to 1.39 (0.90-2.15) for all cases, 1.14 (0.87-1.50) to 1.59 (0.57-4.40) for aggressive disease (American Joint Committee on Cancer stage III/IV or Gleason score 8-10), and 0.91 (0.62-1.35) to 1.02 (1.02-1.04) for nonaggressive disease.
conclusionsOur findings are not consistent with the hypothesis that oxidative balance-related exposures collectively affect risk for prostate cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.