ArticlePsychological review2014
Clarifying the roles of homeostasis and allostasis in physiological regulation.
Article in Psychological review, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
117 citing papers in PubMed.
- The effect of cranial techniques on the heart rate variability response to psychological stress test in firefighter cadets.Scientific reports · 2023Trial
- Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations.Mechanisms of ageing and developmentTrial
- Stress, needs, and behaviour: understanding chronic stress in pet domestic dogs (Canis lupus familiaris) from the prism of needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- A systematic review and empiric examination of the conceptual and analytic overlap between allostatic load and multimorbidity.SSM - population health · 2026Article
- Twenty-Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology.Yeast (Chichester, England) · 2026Review
- Timing the strain: skeletal muscle clock as regulator of physical activity.npj metabolic health and disease · 2026Review
- What homeostasis leaves out: Kinorhesis, a physiological principle of transformation.The Journal of physiology · 2026Article
- Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers-Plasma Biochemistry.Animals : an open access journal from MDPI · 2026Article
- Longitudinal Changes in Thyroid Hormones and Serum Albumin Following CABG, AVR, and PCI: An Exploratory Electronic Medical Record Study.Medical sciences (Basel, Switzerland) · 2026Article
- Violence exposure moderates stress-elicited neurobehavioral function in young people.Emotion (Washington, D.C.) · 2026Article
- Integrating reflex, feedback, and prediction: a tiered model of physiological regulation for contemporary medical education.Frontiers in physiology · 2026Article
- A Bayesian framework for happiness, health, and psychological well-being.Frontiers in psychology · 2026Article
- Arts engagement, active inference, and allostatic regulation: a neurobiological framework for understanding the health effects of aesthetic experience.Frontiers in computational neuroscience · 2026Review
- Understanding negative feedback and classical conditioning of autonomic responses in physiological regulation.Frontiers in physiology · 2026Article
- The Neuroimmunology of Autism.Molecular neurobiology · 2025Review
- Neurophysiological changes associated with dysglycemia in term neonates with neonatal encephalopathy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Heartbeat perception is causally linked to frontal delta oscillations.Communications biology · 2025Article
- Increased breathlessness in post-COVID syndrome despite normal breathing patterns in a rebreathing challenge.Scientific reports · 2025Article
- Revisiting Concepts of Thermal Physiology: Understanding Feedback and Feedforward Control, and Local Temperature Regulation.Acta physiologica (Oxford, England) · 2025Review
- Revisiting concepts of thermal physiology: understanding negative feedback and set-point in mammals, birds, and lizards.Biological reviews of the Cambridge Philosophical Society · 2025Review
57 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
Homeostasis, the dominant explanatory framework for physiological regulation, has undergone significant revision in recent years, with contemporary models differing significantly from the original formulation. Allostasis, an alternative view of physiological regulation, goes beyond its homeostatic roots, offering novel insights relevant to our understanding and treatment of several chronic health conditions. Despite growing enthusiasm for allostasis, the concept remains diffuse, due in part to ambiguity as to how the term is understood and used, impeding meaningful translational and clinical research on allostasis. Here, we provide a more focused understanding of homeostasis and allostasis by explaining how both play a role in physiological regulation, and a critical analysis of regulation suggests how homeostasis and allostasis can be distinguished. Rather than focusing on changes in the value of a regulated variable (e.g., body temperature, body adiposity, or reward), research investigating the activity and relationship among the multiple regulatory loops that influence the value of these regulated variables may be the key to distinguishing homeostasis and allostasis. The mechanisms underlying physiological regulation and dysregulation are likely to have important implications for health and disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.