ArticleJournal of neurology & translational neuroscience2013
Bilateral Synergy: A Framework for Post-Stroke Rehabilitation.
Article in Journal of neurology & translational neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06999876 (The Effect of Combined Transcranial Pulse Current Stimulation), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia: A Double-blind, Sham-controlled, Randomized Controlled Study
Who cites it
32 citing papers in PubMed.
- Bimanual motor skill learning with robotics in chronic stroke: comparison between minimally impaired and moderately impaired patients, and healthy individuals.Journal of neuroengineering and rehabilitation · 2022Trial
- Robot enhanced stroke therapy optimizes rehabilitation (RESTORE): a pilot study.Journal of neuroengineering and rehabilitation · 2021Trial
- Associated Mirror Therapy Enhances Motor Recovery of the Upper Extremity and Daily Function after Stroke: A Randomized Control Study.Neural plasticity · 2021Trial
- Visuomotor information drives interference between the hands more than dynamic motor information during bimanual reaching.Experimental brain research · 2026Article
- A Picture is Worth a Thousand Clinical Assessments: Use of Video-Based Pose Estimation to Augment Post-Stroke Upper Limb Assessment of Bilateral Tasks.Restorative neurology and neuroscience · 2026Article
- Robot-Assisted Mirror Rehabilitation for Post-Stroke Upper Limbs: A Personalized Control Strategy.Sensors (Basel, Switzerland) · 2025Article
- Improving Upper-Limb Recovery in Patients with Chronic Stroke Using an 8-Week Bilateral Arm-Training Device.Life (Basel, Switzerland) · 2025Article
- A Comprehensive Understanding of Postural Tone Biomechanics: Intrinsic Stiffness, Functional Stiffness, Antagonist Coactivation, and COP Dynamics in Post-Stroke Adults.Sensors (Basel, Switzerland) · 2025Article
- Grip and manipulation forces are controlled independently in a coupled bimanual task.Journal of neuroengineering and rehabilitation · 2025Article
- Bilateral arm movements are coordinated via task-dependent negotiations between independent and codependent control, but not by a "coupling" control policy.Journal of neurophysiology · 2023Article
- Force/moment tracking performance during constant-pose, force-varying, bilaterally symmetric, hand-wrist tasks.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2023Article
- Adaptive control is reversed between hands after left hemisphere stroke and lost following right hemisphere stroke.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- How virtual and mechanical coupling impact bimanual tracking.Journal of neurophysiology · 2023Article
- Higher visual gain contributions to bilateral motor synergies and force control.Scientific reports · 2022Article
- Encoder-Controlled Functional Electrical Stimulator for Bilateral Wrist Activities-Design and Evaluation.Bioengineering (Basel, Switzerland) · 2022Article
- Bimanual coordination during reach-to-grasp actions is sensitive to task goal with distinctions between left- and right-hemispheric stroke.Experimental brain research · 2022Article
- Article
- Relationship Between Ipsilesional Upper Extremity Motor Function and Corpus Callosum Integrity in Patients With Unilateral Stroke: A Diffusion Tensor Imaging Study.Brain & NeuroRehabilitation · 2022Article
- Hand dominance in the performance and perceptions of virtual reach control.Acta psychologica · 2022Article
- Bimanual motor impairments in older adults: an updated systematic review and meta-analysis.EXCLI journal · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundUnilateral stroke produces debilitating deficits in voluntary control in the contralesional arm, and significant motor coordination deficits in the ipsilesional arm. In addition, patients tend to avoid bilateral arm patterns and during performance of activities of daily living. Nevertheless, upper extremity physical rehabilitation predominantly focuses on motor training activities with only the paretic arm. This can be limiting because of persistent deficits in the ipsilesional arm, and because of the tendency of patients to avoid spontaneous bilateral arm patterns. PROPOSITION: Rehabilitation should focus on bilateral training to advance recovery of function in both arms of stroke patients, as well as to facilitate spontaneous bilateral arm use. This paper reviews the rationale for this approach, citing evidence for significant hemisphere specific bilateral motor deficits in stroke patients, which affect both the contralesional and the ipsilesional arm. The rationale for, and advantages of, training both arms simultaneously through bilateral tasks is reviewed. Although bilateral training has been employed to treat stroke patients previously, this has tended to focus on bimanual 'coupling' as a rationale for performing parallel, but not cooperative bilateral tasks. Bilateral synergy provides a more functional framework for structuring post-stroke upper extremity rehabilitation.
conclusionBilateral synergy may be causally linked to spontaneous bilateral arm use, suggesting that rehabilitation should be focused on bilateral cooperative tasks, such as bilateral object transport. Further research is required to determine whether this approach could be efficacious for patients with hemiparesis, and whether both left and right hemisphere strokes can benefit from such intervention.
Indexed as
Identifiers
24729985PMC3984050What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.