ReviewAging and disease2014
Gender differences, aging and hormonal status in mucosal injury and repair.
Review in Aging and disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
- Development of an Explainable Machine Learning Model for Predicting Reflux Esophagitis Among Candidates for Metabolic Bariatric Surgery.Obesity surgery · 2026Article
- Sex and Gender Perspective in Obesity and Gastric Cancer.The world journal of men's health · 2026Review
- Menopause and "leaky gut": implications for midlife women's health.The Journal of clinical investigation · 2026Article
- Development and Internal Validation of a Nomogram for Predicting Reflux Esophagitis in Candidates for Metabolic Bariatric Surgery.Obesity surgery · 2026Article
- Perioperative nonsteroidal anti-inflammatory drugs and the risk for anastomotic leakage in patients undergoing major gastrointestinal surgery: a retrospective cohort study.BMC anesthesiology · 2025Article
- Association of female reproductive traits with altered aging trajectories: Insights from genetic and observational analyses.Cell reports. Medicine · 2025Observational
- Association between menopause, postmenopausal hormone therapy and peptic ulcer disease in Taiwanese population.Scientific reports · 2025Article
- Global, regional, and national burdens of PUD in women of reproductive age from 1992 to 2021: a trend analysis based on the global burden of disease study 2021.Frontiers in global women's health · 2025Article
- [The Relationship of Dysbiosis of Duodenal Microbiome and Functional Dyspepsia].The Korean journal of helicobacter and upper gastrointestinal research · 2024Review
- The Role of Estrogen across Multiple Disease Mechanisms.Current issues in molecular biology · 2024Review
- Sex difference in the associations among risk factors with gastroesophageal reflux disease in a large Taiwanese population study.BMC gastroenterology · 2024Article
- Predictive Factors for the Outcome of Unsupervised Endoscopic Submucosal Dissection During the Initial Learning Curve with Prevalence-Based Indication.Digestive diseases and sciences · 2023Article
- Intestinal epithelial stem cell transplants as a novel therapy for cerebrovascular stroke.Brain, behavior, and immunity · 2023Article
- Review
- Impact of Age and Sex on Electrical Impedance Values in Healthy Oral Mucosa.Bioengineering (Basel, Switzerland) · 2022Article
- Potential utility of a non-invasive menstrual blood immunophenotype analysis in reproductive medicine.Reproduction & fertility · 2022Article
- Bladder Microbiota Are Associated with Clinical Conditions That Extend beyond the Urinary Tract.Microorganisms · 2022Article
- Multisite prospective Liver Disease and Reproductive Ageing (LIVRA) study in US women living with and without HIV.BMJ open · 2022Article
- The Reproductive Transition: Effects on Viral Replication, Immune Activation, and Metabolism in Women with HIV infection.Current HIV/AIDS reports · 2022Review
- Menopause Is Associated With Immune Activation in Women With HIV.The Journal of infectious diseases · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
As the "baby boomers" age, the percentage of the population over sixty-five years of age is increasing rapidly. Chronic disease management is an important component in the care of the elderly. The effects of aging on different organ systems are also pertinent; such as the weakening homeostatic response to injury in the older individuals. Mucosal surfaces have the largest combined surface area in the body and are the site of important host microbe interactions, especially in the gut which is prone to injury, both from local and systemic insult. This susceptibility has been known to increase with age. Therefore it is important to understand the interplay between aging, injury and recovery at the mucosal surface. Sex hormones play an important role in the maintenance of the mucosal barrier function as well as the mucosa associated immune function in both genders. Menopause in women is a defined time period in which major hormonal changes occur such as a decline in systemic estradiol levels. The differential levels of sex hormones contribute to the sexual dimorphism seen in response to injury at the mucosal surface, prior to and following menopause. Thus the effect of sex hormone and aging on mucosal mechanisms in response to injury is an important area of investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.