ReviewAging and disease2014
Sepsis in old age: review of human and animal studies.
Review in Aging and disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 153 citations in OpenAlex.
- Coordinated response of vascular and glial cells in a pig model of sepsis.Translational psychiatry · 2026Article
- Experimental robustness and reproducibility of the murine cecal ligation and puncture sepsis model.Intensive care medicine experimental · 2026Article
- Sepsis in Frail Older Adults: Tailored Antimicrobial Stewardship and Individualized Care Approach.Antibiotics (Basel, Switzerland) · 2026Review
- Age-Associated Impairment of Paneth Cells Driven by microRNA-152 Promotes Intestinal Epithelial Vulnerability to Pathological Stress.Aging cell · 2026Article
- Distinct patterns of endothelial response to endotoxin in aged mice as compared to young mice.GeroScience · 2026Article
- Optimization of Preclinical Rodent Research Models of Human Shock: Part One Intra-Abdominal Sepsis.Shock (Augusta, Ga.) · 2026Review
- GDF3 promotes adipose tissue macrophage-mediated inflammation via altered chromatin accessibility during aging.Nature aging · 2026Article
- Age-related epidemiology and outcomes of sepsis in Japanese critical care units: a nationwide administrative claims database study.Journal of intensive care · 2025Article
- Nationwide trends and disparities in deaths following cardiogenic shock and sepsis in the United States (1999-2023): insights from the CDC WONDER database.BMC cardiovascular disorders · 2025Article
- Impact of community-acquired invasive Escherichia coli disease on mortality and readmissions in elderly patients: a multi-center study in Germany.BMC infectious diseases · 2025Article
- Construction and validation of a prediction model for short-term mortality risk in elderly patients with sepsis: a retrospective study.BMC infectious diseases · 2025Article
- Aging-induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Coagulation Parameters in Elderly Patients with Severe Pneumonia: Correlation with Disease Severity and Prognosis.Infection and drug resistance · 2025Article
- Association of vitamin A and D deficiency and the presence of sepsis in the geriatric population: a cross-sectional study.Frontiers in nutrition · 2025Article
- A Practical Nomogram Based on RDW-CV for Predicting Clinical Outcome in Elderly Septic Patients.Infection and drug resistance · 2025Article
- Mortality trends in elderly patients with disseminated intravascular coagulation: a retrospective CDC WONDER Analysis (1999-2020).Archives of medical sciences. Atherosclerotic diseases · 2025Article
- Factors influencing sepsis associated thrombocytopenia (SAT): A multicenter retrospective cohort study.PloS one · 2025Observational
- Review
- Deep reinforcement learning extracts the optimal sepsis treatment policy from treatment records.Communications medicine · 2024Article
- Correlation of HCT-ALB, SmtO2, CRT and LAC with renal impairment and prognosis in patients with septic shock.Journal of medical biochemistry · 2024Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sepsis is a serious problem among the geriatric population as its incidence and mortality rates dramatically increase with advanced age. Despite a large number of ongoing clinical and basic research studies, there is currently no effective therapeutic strategy that rescues elderly patients with severe sepsis. Recognition of this problem is relatively low as compared to other age-associated diseases. The disparity between clinical and basic studies is a problem, and this is likely due, in part, to the fact that most laboratory animals used for sepsis research are not old while the majority of sepsis cases occur in the geriatric population. The objective of this article is to review recent epidemiological studies and clinical observations, and compare these with findings from basic laboratory studies which have used aged animals in experimental sepsis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.