ArticleInternational neurourology journal2014
Treadmill exercise ameliorates short-term memory disturbance in scopolamine-induced amnesia rats.
Article in International neurourology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Trazodone modulates behavioral alterations in scopolamine-induced cognitive deficit by targeting brain-derived neurotropic factor and cAMP response element-binding protein signaling.Frontiers in cellular neuroscience · 2025Article
- Article
- Protective effect of mangiferin on memory impairment: A systematic review.Saudi journal of biological sciences · 2021Review
- Neuroprotective roles of total flavones of Camellia on early brain injury andcognitive dysfunction following subarachnoid hemorrhage in rats.Metabolic brain disease · 2020Article
- Exercise and Neuroinflammation in Health and Disease.International neurourology journal · 2019Article
- Neuroprotective effects of exercise in rodent models of memory deficit and Alzheimer's.Metabolic brain disease · 2019Review
- Ethanolic Extract ofFrontiers in pharmacology · 2019Article
- The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging.Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Amelioration of Cognitive Deficit by Embelin in a Scopolamine-Induced Alzheimer's Disease-Like Condition in a Rat Model.Frontiers in pharmacology · 2018Article
- Treadmill exercise ameliorates intracerebral hemorrhage-induced depression in rats.Journal of exercise rehabilitation · 2016Article
- Electroacupuncture improves cognitive ability following cerebral ischemia reperfusion injury via CaM-CaMKIV-CREB signaling in the rat hippocampus.Experimental and therapeutic medicine · 2016Article
- Treadmill exercise ameliorates motor dysfunction through inhibition of Purkinje cell loss in cerebellum of valproic acid-induced autistic rats.Journal of exercise rehabilitation · 2016Article
- Postnatal Treadmill Exercise Alleviates Prenatal Stress-Induced Anxiety in Offspring Rats by Enhancing Cell Proliferation Through 5-Hydroxytryptamine 1A Receptor Activation.International neurourology journal · 2016Article
- Effects of surgical and chemical castration on spatial learning ability in relation to cell proliferation and apoptosis in hippocampus.International urology and nephrology · 2016Article
- miR21 is Associated with the Cognitive Improvement Following Voluntary Running Wheel Exercise in TBI Mice.Journal of molecular neuroscience : MN · 2015Article
- Treadmill exercise prevents GABAergic neuronal loss with suppression of neuronal activation in the pilocarpine-induced epileptic rats.Journal of exercise rehabilitation · 2015Article
- Treadmill exercise improves motor coordination through ameliorating Purkinje cell loss in amyloid beta23-35-induced Alzheimer's disease rats.Journal of exercise rehabilitation · 2014Article
- Effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats.Journal of exercise rehabilitation · 2014Article
- Long-term administration of scopolamine interferes with nerve cell proliferation, differentiation and migration in adult mouse hippocampal dentate gyrus, but it does not induce cell death.Neural regeneration research · 2014Article
- Postnatal treadmill exercise alleviates short-term memory impairment by enhancing cell proliferation and suppressing apoptosis in the hippocampus of rat pups born to diabetic rats.Journal of exercise rehabilitation · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeScopolamine is a nonselective muscarinic cholinergic receptor antagonist, which induces impairment of learning ability and memory function. Exercise is known to ameliorate brain disturbance induced by brain injuries. In the present study, we investigated the effect of treadmill exercise on short-term memory in relation to acetylcholinesterase (AChE) expression in the hippocampus, using a scopolamine-induced amnesia model in mice.
methodsTo induce amnesia, 1 mg/kg scopolamine hydrobromide was administered intraperitoneally once per day for 14 days. A step-down avoidance test for short-term memory was conducted. AChE histochemistry, immunohistochemistry for collagen IV, and doublecortin were performed.
resultsShort-term memory deteriorated in the mice with scopolamine-induced amnesia, concomitant with enhanced AChE expression and suppression of angiogenesis in the hippocampus. Critically, treadmill exercise ameliorated short-term memory impairment, suppressed AChE expression, and enhanced angiogenesis in the mice with scopolamine-induced amnesia.
conclusionsOverexpression of AChE is implicated in both brain and renal disease. The findings of our study indicate that treadmill exercise may be of therapeutic value in neurodegenerative and renal diseases by suppressing the effects of AChE expression.
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