Evidence map›Paper›PMID 24729881›Full record

ArticleISRN hematology2014

Pretransplant comorbidities maintain their impact on allogeneic stem cell transplantation outcome 5 years posttransplant: a retrospective study in a single german institution.

Jens M Chemnitz, Geothy Chakupurakal, Maya Bäßler, Udo Holtick, Sebastian Theurich, Alexander Shimabukuro-Vornhagen, Silke Leitzke, Michael S Von Bergwelt-Baildon, Christof Scheid

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ISRN hematology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jens M ChemnitzBMT Program, Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50924 Köln, Germany.
Geothy ChakupurakalBMT Program, Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50924 Köln, Germany.ORCID 0000-0002-7706-8447
Maya BäßlerBMT Program, Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50924 Köln, Germany.
Udo HoltickBMT Program, Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50924 Köln, Germany.
Sebastian TheurichBMT Program, Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50924 Köln, Germany.ORCID 0000-0001-5706-8258
Alexander Shimabukuro-VornhagenBMT Program, Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50924 Köln, Germany.
Silke LeitzkeBMT Program, Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50924 Köln, Germany.
Michael S Von Bergwelt-BaildonBMT Program, Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50924 Köln, Germany.
Christof ScheidBMT Program, Department I of Internal Medicine, University Hospital Cologne, Kerpener Straße 62, 50924 Köln, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The introduction of reduced-intensity conditioning regimens has allowed elderly patients with preexisting comorbidities access to the potentially curative allogeneic stem cell transplantation. Patient's comorbidities at the time of treatment consideration play a significant role in transplant outcome in terms of both overall survival (OS) and nonrelapse mortality (NRM). The hematopoietic stem cell transplantation comorbidity index (HCT-CI) quantifies these patient specific risks and has established itself as a major tool in the pretransplant assessment of patients. Many single center and multicenter studies have assessed the HCT-CI score and reported conflicting outcomes. The present study aimed to evaluate the HCT-CI in a single large European transplant centre. 245 patients were retrospectively analyzed and the predictive value of the score was assessed with respect to OS and NRM. We confirm that the HCT-CI predicts outcome for both OS and NRM. Moreover, we identified age of the patient as an independent prognostic parameter for OS. Incorporation of age in the HCT-CI would improve its ability to prognosticate and allow the transplant physician to assess the patient specific risks appropriately at the time of counseling for transplant.

Identifiers

PMID24729881
PMCPMC3963108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.