Evidence map›Paper›PMID 24729869›Full record

ArticleJournal of materials chemistry. B2014

Glycoprotein CD98 as a receptor for colitis-targeted delivery of nanoparticle.

Bo Xiao, Yang Yang, Emilie Viennois, Yuchen Zhang, Saravanan Ayyadurai, Mark Baker, Hamed Laroui, Didier Merlin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

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  8. Immunomodulation in age-related disorders and nanotechnology interventions.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2023
    Review
  9. Novel drug delivery systems for inflammatory bowel disease.World journal of gastroenterology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bo XiaoCenter for Diagnostics and Therapeutics, Department of Biology and Chemistry, Georgia State University, Atlanta, 30302, USA. ; Tel: +1-404-413-3597.
Yang YangCenter for Diagnostics and Therapeutics, Department of Biology and Chemistry, Georgia State University, Atlanta, 30302, USA. ; Tel: +1-404-413-3597.
Emilie ViennoisCenter for Diagnostics and Therapeutics, Department of Biology and Chemistry, Georgia State University, Atlanta, 30302, USA. ; Tel: +1-404-413-3597 ; Atlanta Veterans Affairs Medical Center, Decatur, 30033, USA.
Yuchen ZhangCenter for Diagnostics and Therapeutics, Department of Biology and Chemistry, Georgia State University, Atlanta, 30302, USA. ; Tel: +1-404-413-3597.
Saravanan AyyaduraiCenter for Diagnostics and Therapeutics, Department of Biology and Chemistry, Georgia State University, Atlanta, 30302, USA. ; Tel: +1-404-413-3597.
Mark BakerCenter for Diagnostics and Therapeutics, Department of Biology and Chemistry, Georgia State University, Atlanta, 30302, USA. ; Tel: +1-404-413-3597.
Hamed LarouiCenter for Diagnostics and Therapeutics, Department of Biology and Chemistry, Georgia State University, Atlanta, 30302, USA. ; Tel: +1-404-413-3597.
Didier MerlinCenter for Diagnostics and Therapeutics, Department of Biology and Chemistry, Georgia State University, Atlanta, 30302, USA. ; Tel: +1-404-413-3597 ; Atlanta Veterans Affairs Medical Center, Decatur, 30033, USA.
Georgia State University · USVeterans Health Administration · US

Funding

ROLE OF CD98 IN INTESTINAL PERMEABILITYR01DK071594 · NIDDK · GEORGIA STATE UNIVERSITY · PI MERLIN, DIDIER · 2006 to 2017
$3.3M
Role of CD98 Glycoprotein in Intestinal InflammationK01DK097192 · NIDDK · GEORGIA STATE UNIVERSITY · PI LAROUI, HAMED · 2012 to 2016
$500k
NIDDK NIH HHS K01 DK097192NIDDK NIH HHS R01 DK071594
6 · The paper itself

Abstract

Treatment strategies for inflammatory bowel disease have been constrained by limited therapeutic efficacy and serious adverse effects owing to a lack of receptor for targeted drug delivery to the inflamed colon. Upon inflammation, CD98 expression is highly elevated in colonic epithelial cells and infiltrating immune cells. To investigate whether CD98 can be used as a colitis-targeted delivery receptor, we constructed CD98 Fab'-bearing quantum dots (QDs)-loaded nanoparticles (Fab'-NPs). The resultant Fab'-NPs had desired particle size (~458 nm) with a narrow size distribution and zeta-potential (approximately +19 mV), low cytotoxicity, and excellent fluorescence properties. Electron microscopy images provided direct evidence for the well-dispersed distribution of QDs within spherical Fab'-NPs. Cellular uptake experiments demonstrated that Fab'-NPs were efficiently internalized into Colon-26 and RAW 264.7 cells through the CD98-mediated endocytosis pathway, and showed that the targeting effect of CD98 Fab' markedly increased their cellular uptake efficiency compared with control pegylated QDs-loaded NPs (PEG-NPs). Furthermore,

Identifiers

PMID24729869
PMCPMC3981968
OpenAlexW1966063759

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.