ArticleKorean journal of anesthesiology2014
Reduction in labor pain by intrathecal midazolam as an adjunct to sufentanil.
Article in Korean journal of anesthesiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Dexamethasone as a sufentanil adjuvant effects on labor pain management and neonatal safety.Annals of medicine and surgery (2012) · 2025Article
- Article
- The potential value of exosomes as adjuvants for novel biologic local anesthetics.Frontiers in pharmacology · 2023Review
- Viscous lidocaine solution versus lidocaine spray for pharyngeal local anesthesia in upper gastroesophageal endoscopy.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
- A comparison of the effects of ENTONOX inhalation and spinal anesthesia on labor pain reduction and apgar score in vaginal delivery: a clinical trial study.BioMedicine · 2018Article
- Intrathecal Midazolam as an Adjuvant in Pregnancy-Induced Hypertensive Patients Undergoing an Elective Caesarean Section: A Clinical Comparative Study.Anesthesiology and pain medicine · 2016Article
- [Neuraxial labor analgesia: a literature review: a letter to the editor].Brazilian journal of anesthesiology (Elsevier)Article
- Efficacy of intrathecal midazolam in potentiating the analgesic effect of intrathecal fentanyl in patients undergoing lower limb surgery.Anesthesia, essays and researchesArticle
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Authors and funding
6 authors.
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Abstract
backgroundAnesthesia today has strived to decrease labor pain in a tolerable and controllable fashion. Intrathecal midazolam has been introduced as an adjunct to analgesics. The study was planned to assess the efficacy, safety and duration of analgesia produced by intrathecal midazolam adjunct to sufentanil in decreasing labor pain.
methodsIn a randomized clinical trial 80 parturient included in the study. The two groups were matched for age, cervical dilation, gravid, gestational age, and other demographic characteristics. Combination of sufentanil and midazolam administered intrathecally to experimental group and compared to sufentanil group. Time to reach maximum block, and pain score was measured and recorded.
resultsGroups were matched for age and weight and other demographic characteristic. No significant adverse effect was seen in both groups including decrease in Apgar score. Duration of analgesia was 92.0 ± 12.7 in sufentanil group and 185.2 ± 15.2 minutes in midazolam and sufentanil group which was significantly different (P = 0.002). Numeric rating scale score was significantly lower in midazolam group compare to sufentanil group at 120 min (P = 0.01), 150 min (P = 0.0014), and 180 min (P = 0.001).
conclusionsIntrathecal midazolam as an adjunct to opioid could significantly enhance analgesia in labor pain with no significant adverse effect. Intrathecal injection of midazolam is an appropriate alternative to parenteral or epidural analgesia in small hospital settings.
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