Evidence map›Paper›PMID 24729835›Full record

ArticleJournal of computational interdisciplinary sciences2012

Recovery from stress - a cell cycle perspective.

Elahe Radmaneshfar, Marco Thiel

Abstract read
In one paragraph

Article in Journal of computational interdisciplinary sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elahe RadmaneshfarInstitute for Complex Systems and Mathematical Biology, SUPA, University of Aberdeen, Aberdeen, AB24 3UE, UK.
Marco ThielInstitute for Complex Systems and Mathematical Biology, SUPA, University of Aberdeen, Aberdeen, AB24 3UE, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/F00513X/1
6 · The paper itself

Abstract

We develop a Boolean model to explore the dynamical behaviour of budding yeast in response to osmotic and pheromone stress. Our model predicts that osmotic stress halts the cell cycle progression in either of four possible arrest points. The state of the cell at the onset of the stress dictates which arrest point is finally reached. According to our study and consistent with biological data, these cells can return to the cell cycle after removal of the stress. Moreover, the Boolean model illustrates how osmotic stress alters the state transitions of the cell. Furthermore, we investigate the influence of a particular pheromone based method for the synchronisation of the cell cycles in a population of cells. We show this technique is not a suitable method to study one of the arrest points under osmotic stress. Finally, we discuss how an osmotic stress can cause some of the so called

Indexed as

alpha factorBoolean networkcell cycleosmotic stressstate transitionstress response

Identifiers

PMID24729835
PMCPMC3982136

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.