Evidence map›Paper›PMID 24729834›Full record

ArticleACS medicinal chemistry letters2013

Trisubstituted Sulfonamides: a New Chemotype for Development of Potent and Selective CB

Qin Ouyang, Qin Tong, Rentian Feng, Kyaw-Zeyar Myint, Peng Yang, Xiang-Qun Xie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Qin OuyangDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
Qin TongDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Rentian FengDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Kyaw-Zeyar MyintDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Peng YangDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Xiang-Qun XieDepartment of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; Pittsburgh Chemical Methods and Library Development Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA ; Department of Structural Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
University of Pittsburgh · USArmy Medical University · CN

Funding

Structure/Function of the CB2 Receptor Binding and G-protein Recognition PocketsR01DA025612 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, XIANG-QUN · 2010 to 2014
$1.7M
NIDA NIH HHS R01 DA025612
6 · The paper itself

Abstract

An extensive exploration of the SAR of a trisubstituted sulfonamides series led to the identification of

Indexed as

cannabinoid receptorsinverse agonistsosteoclast inhibitorstrisubstituted sulfonamides

Identifiers

PMID24729834
PMCPMC3979583
OpenAlexW2021514544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.