Evidence map›Paper›PMID 24729635›Full record

ArticleMolecular physics2014

Aromatic interactions impact ligand binding and function at serotonin 5-HT

Tania Córdova-Sintjago, Nancy Villa, Lijuan Fang, Raymond G Booth

Open access · greenAbstract read
In one paragraph

Article in Molecular physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Deciphering the allosteric landscape of 5-HTPharmacological reports : PR · 2026
    Article
  2. Coumarin benzamide scaffold as potential 5-HTJournal of molecular modeling · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tania Córdova-SintjagoDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610 USA.
Nancy VillaDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610 USA.
Lijuan FangDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610 USA.
Raymond G BoothDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610 USA ; Center for Drug Discovery, Departments of Pharmaceutical Sciences, and, Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115 USA.
University of Florida · US

Funding

Serotonin 5HT2C Agonist Drugs with 5HT2A/2B Antagonist ActivityR01MH081193 · NIMH · UNIVERSITY OF FLORIDA · PI BOOTH, RAYMOND G. · 2008 to 2012
$1.8M
Novel Functionally-Selective Serotonin 5HT2 Drugs for Amphetamines Abuse/DisorderR01DA030989 · NIDA · UNIVERSITY OF FLORIDA · PI BOOTH, RAYMOND G., MORGAN, DRAKE · 2010 to 2014
$1.6M
Novel 5HT2C Agonist Drugs with 5HT2A Antagonist Activity for Cocaine AddictionR01DA023928 · NIDA · UNIVERSITY OF FLORIDA · PI BOOTH, RAYMOND G. · 2007 to 2010
$1.5M
NIDA NIH HHS R01 DA023928NIDA NIH HHS R01 DA030989NIMH NIH HHS R01 MH081193
6 · The paper itself

Abstract

The serotonin (5-hydroxytryptamine, 5-HT) 5-HT

Indexed as

Aromatic Interactionsdockingdrug designF6.51F6.52GPCRhomology modelingmolecular dynamicsSerotonin 5-HT2CW6.48

Identifiers

PMID24729635
PMCPMC3979624
OpenAlexW2048600218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.