ArticleMedical oncology (Northwood, London, England)2014
EYA1 expression in gastric carcinoma and its association with clinicopathological characteristics: a pilot study.
Article in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- A single-cell atlas revealing cellular heterogeneity across healthy and diseased human thymus.Nature communications · 2026Article
- The deubiquitinase OTUB1 fosters papillary thyroid carcinoma growth through EYA1 stabilization.Journal of cellular and molecular medicine · 2021Article
- Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review.Clinical and experimental gastroenterology · 2020Review
- EYA1 promotes cell migration and tumor metastasis in hepatocellular carcinoma.American journal of translational research · 2019Article
- Eyes absent gene (EYA1) is a pathogenic driver and a therapeutic target for melanoma.Oncotarget · 2017Article
- Augmented expression levels of lncRNAsIranian journal of basic medical sciences · 2017Article
- EYA1 expression and subcellular localization in neuroblastoma and its association with prognostic markers.Journal of cancer research & therapy · 2016Article
- Autoantibody Profiling of Glioma Serum Samples to Identify Biomarkers Using Human Proteome Arrays.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the second most frequent cause of cancer death, gastric cancer is a common disease worldwide. Most of the patients are being diagnosed in the stage that conventional treatments are not effective, and invasion and metastases lead to death. So, identification of novel molecular markers to improve early diagnosis, prognosis and treatment of the gastric cancer is a necessity. EYA1 is a member of EYA family which their deregulation has been demonstrated in several types of cancer. The aim of this study was to assess EYA1 gene expression in tissues of the gastric cancer patients and to investigate its correlation with clinicopathological parameters. A total of 60 tumor and non-tumor gastric specimens were evaluated for EYA1 gene expression using quantitative real-time PCR. The EYA1 expression decreased significantly in gastric tumor tissues compared with adjacent normal tissues. We further showed that there was a negative correlation between the EYA1 gene expression levels, tumor size, lymphatic invasion and distant metastasis. In conclusion, EYA1 might be used as a potential biomarker for monitoring gastric carcinoma progression rate. Further studies to determine the mechanism of action of EYA1 is needed to unravel the role of this gene in gastric cancer pathogenesis.
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Registered trials
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