ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2014
Sequence-specific flexibility organization of splicing flanking sequence and prediction of splice sites in the human genome.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A high-performance approach for predicting donor splice sites based on short window size and imbalanced large samples.Biology direct · 2019Article
- Sequence-based predictive modeling to identify cancerlectins.Oncotarget · 2017Article
- The OsCYP19-4 Gene Is Expressed as Multiple Alternatively Spliced Transcripts Encoding Isoforms with Distinct Cellular Localizations and PPIase Activities under Cold Stress.International journal of molecular sciences · 2016Article
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Authors and funding
7 authors.
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Abstract
More and more reported results of nucleosome positioning and histone modifications showed that DNA structure play a well-established role in splicing. In this study, a set of DNA geometric flexibility parameters originated from molecular dynamics (MD) simulations were introduced to discuss the structure organization around splice sites at the DNA level. The obtained profiles of specific flexibility/stiffness around splice sites indicated that the DNA physical-geometry deformation could be used as an alternative way to describe the splicing junction region. In combination with structural flexibility as discriminatory parameter, we developed a hybrid computational model for predicting potential splicing sites. And the better prediction performance was achieved when the benchmark dataset evaluated. Our results showed that the mechanical deformability character of a splice junction is closely correlated with both the splice site strength and structural information in its flanking sequences.
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