ArticleIndian journal of pediatrics2014
Hemophagocytic lymphohistiocytosis syndrome in Dengue hemorrhagic fever.
Article in Indian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Cytokine Storm Syndrome Associated with Hemorrhagic Fever and Other Viruses.Advances in experimental medicine and biology · 2024Review
- Complicated Dengue Fever and Its Treatment Dilemmas: A Single-Center Experience in Sri Lanka.Case reports in infectious diseases · 2021Article
- Dengue Infection Complicated by Hemophagocytic Lymphohistiocytosis: Experiences From 180 Patients With Severe Dengue.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Severe Dengue and Associated Hemophagocytic Lymphohistiocytosis in PICU.Indian journal of pediatrics · 2019Article
- Beyond thrombocytopaenia, haemorrhage and shock: the expanded dengue syndrome.Pathogens and global health · 2018Review
- Article
- Incidence and Risk Factors for Developing Dengue-Associated Hemophagocytic Lymphohistiocytosis in Puerto Rico, 2008 - 2013.PLoS neglected tropical diseases · 2016Article
- Macrophage Activation Syndrome.Indian journal of pediatrics · 2016Review
- Hemophagocytic lymphohistiocytosis syndrome in dengue hemorrhagic Fever: authors' reply.Indian journal of pediatrics · 2015Article
- Hemophagocytic lymphohistiocytosis syndrome in dengue hemorrhagic Fever: correspondence.Indian journal of pediatrics · 2015Article
- Hemophagocytic lymphohistiocytosis secondary to hemodialysis catheter-related blood stream infection.Indian journal of nephrologyArticle
- Dengue: Moving from Current Standard of Care to State-of-the-Art Treatment.Current treatment options in infectious diseasesReview
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a life threatening florid activation of macrophages of the lymphoreticular system. It is reported to be associated with dengue in children in India and carries a high mortality. Patients present with high fever, worsening blood cell counts, splenomegaly, abnormal liver enzymes with features of liver failure, coagulopathy and neurological complications. The diagnosis is according to "Diagnostic Guidelines for HLH 2004", based on a triad of clinical, blood parameters and bone marrow cytology. In the present study, data of 212 children admitted with dengue were analyzed. Of 212 children, 31 children were classified as suspect HLH and advised bone marrow evaluation; of whom 23 children had marrow evidence of HLH. Worsening of blood cell counts were recorded in all children with a mean platelet count of 58,303.03 cells/cumm, low hematocrit in 95.65 %, low mean hemoglobin level of 8.37 g/dL, high erythrocyte sedimentation rate (ESR) and prolonged pro-thrombin time/international normalization ratio (PT/INR). Serum triglycerides, ferritin and transaminases were high. Of the 23 children, 19 patients received intravenous immunoglobulin (IVIG) and all of these children recovered. Dengue with multi-organ dysfunction is commonly concurrent to HLH in the marrow and hence, an early diagnosis based on clinical, laboratory and bone marrow evaluation is significant. A bone marrow evaluation confirms the diagnosis of HLH.
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