ArticlePsychopharmacology2014
Developmental alterations in anxiety and cognitive behavior in serotonin transporter mutant mice.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Serotonin Transporter Gene 5-HTTLPR Polymorphism as a Protective Factor Against the Progression of Post-Stroke Depression.Molecular neurobiology · 2016Pooled it
- Serotonin transporter knockout in rats reduces beta- and gamma-band functional connectivity between the orbitofrontal cortex and amygdala during auditory discrimination.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Impairments of social interaction in a valproic acid model in mice.Frontiers in behavioral neuroscience · 2024Article
- Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.Molecular brain · 2023Article
- Fear Extinction and Predictive Trait-Like Inter-Individual Differences in Rats Lacking the Serotonin Transporter.International journal of molecular sciences · 2021Article
- Alterations in the autonomic nerve activities of prenatal autism model mice treated with valproic acid at different developmental stages.Scientific reports · 2020Article
- Serotonin transporter deficiency alters socioemotional ultrasonic communication in rats.Scientific reports · 2019Article
- Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.Neuropsychopharmacology reports · 2019Article
- Impaired Fear Extinction Recall in Serotonin Transporter Knockout Rats Is Transiently Alleviated during Adolescence.Brain sciences · 2019Article
- Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis.BMC neuroscience · 2018Article
- Anxiolytic- and Antidepressant-Like Effects of Fish Oil-Enriched Diet in Brain-Derived Neurotrophic Factor Deficient Mice.Frontiers in neuroscience · 2018Article
- Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons.Neuroscience · 2017Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
rationaleA promoter variant of the serotonin transporter (SERT) gene is known to affect emotional and cognitive regulation. In particular, the "short" allelic variant is implicated in the etiology of multiple neuropsychiatric disorders. Heterozygous (SERT(+/-)) and homozygous (SERT(-/-)) SERT mutant mice are valuable tools for understanding the mechanisms of altered SERT levels. Although these genetic effects are well investigated in adulthood, the developmental trajectory of altered SERT levels for behavior has not been investigated.
objectivesWe assessed anxiety-like and cognitive behaviors in SERT mutant mice in early adolescence and adulthood to examine the developmental consequences of reduced SERT levels. Spine density of pyramidal neurons was also measured in corticolimbic brain regions.
resultsAdult SERT(-/-) mice exhibited increased anxiety-like behavior, but these differences were not observed in early adolescent SERT(-/-) mice. Conversely, SERT(+/-) and SERT(-/-) mice did display higher spontaneous alternation during early adolescence and adulthood. SERT(+/-) and SERT(-/-) also exhibited greater neuronal spine densities in the orbitofrontal but not the medial prefrontal cortices. Adult SERT(-/-) mice also showed an increased spine density in the basolateral amygdala.
conclusionsDevelopmental alterations of the serotonergic system caused by genetic inactivation of SERT can have different influences on anxiety-like and cognitive behaviors through early adolescence into adulthood, which may be associated with changes of spine density in the prefrontal cortex and amygdala. The altered maturation of serotonergic systems may lead to specific age-related vulnerabilities to psychopathologies that develop during adolescence.
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Registered trials
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